{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:11:15Z","timestamp":1789499475074,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1126229"],"award-info":[{"award-number":["1126229"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This preliminary study quantified tibia cartilage thickness (Cart.Th), subchondral bone plate thickness (SBPl.Th)\u00a0and subchondral trabecular bone (STB) microarchitecture in subjects with varus\u2010 or valgus\u2010 malaligned knees diagnosed with end\u2010stage knee osteoarthritis (OA) and compared them to controls (non\u2010OA). Tibial plateaus from 25 subjects with knee\u2010OA (undergoing knee arthroplasty) and 15 cadavers (controls) were micro\u2010CT scanned (17\u2009\u00b5m\/voxel). Joint alignment was classified radiographically for OA subjects (varus\u2010aligned <jats:italic>n<\/jats:italic>\u2009=\u200918, valgus\u2010aligned <jats:italic>n<\/jats:italic>\u2009=\u20097). Cart.Th, SBPl.Th, STB bone volume fraction (BV\/TV) and their medial\u2010to\u2010lateral ratios were analyzed in anteromedial, anterolateral, posteromedial and posterolateral subregions. Varus\u2010OA and valgus\u2010OA were compared to controls. Compared to controls (1.19\u20131.54\u2009mm), Cart.Th in varus\u2010OA was significantly lower anteromedially (0.58\u2009mm, \u221259%) and higher laterally (2.19\u20132.47\u2009mm,\u00a0+60\u201363%); in valgus\u2010OA, Cart.Th was significantly higher posteromedially (1.86\u2009mm,\u00a0+56%). Control medial\u2010to\u2010lateral Cart.Th ratios were around unity (0.8\u20131.1), in varus\u2010OA significantly below (0.2\u20130.6) and in valgus\u2010OA slightly above (1.0\u20131.3) controls. SBPl.Th and BV\/TV were significantly higher medially in varus\u2010OA (0.58\u20100.72\u2009mm and 37\u201344%, respectively) and laterally in valgus\u2010OA (0.60\u20130.61\u2009mm and 32\u201337%), compared to controls (0.26\u20130.47\u2009mm and 18\u201337%). In varus\u2010OA, the medial\u2010to\u2010lateral SBPl.Th and BV\/TV ratios were above unity (1.4\u20132.4) and controls (0.8\u20132.1); in valgus\u2010OA they were closer to unity (0.8\u20101.1) and below controls. Varus\u2010 and valgus\u2010OA tibia differ significantly from controls in Cart.Th, SBPl.Th\u00a0and STB microarchitecture depending on joint alignment, suggesting structural changes in OA may reflect differences in medial\u2010to\u2010lateral load distribution upon the tibial plateau. Here we identified an inverse relationship between cartilage thickness and underlying subchondral bone, suggesting a whole\u2010joint response in OA to daily stimuli.<\/jats:p>","DOI":"10.1002\/jor.24914","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T06:27:31Z","timestamp":1606372051000},"page":"1988-1999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Tibial cartilage, subchondral bone plate and trabecular bone microarchitecture in varus\u2010\u00a0and valgus\u2010osteoarthritis versus controls"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-1741","authenticated-orcid":false,"given":"Sophie","family":"Rapagna","sequence":"first","affiliation":[{"name":"Medical Device Research Institute, College of Science and Engineering Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8094-6140","authenticated-orcid":false,"given":"Bryant C.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Medical Device Research Institute, College of Science and Engineering Flinders University  Adelaide South Australia Australia"},{"name":"Department of Oncology and Metabolism, Insigneo Institute for\u00a0In Silico\u00a0Medicine The University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-2372","authenticated-orcid":false,"given":"Lucian B.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Centre for Orthopaedic and Trauma Research The University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Orthopaedics and Trauma Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-1610","authenticated-orcid":false,"given":"Karen J.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Medical Device Research Institute, College of Science and Engineering Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6614-8663","authenticated-orcid":false,"given":"Dominic","family":"Thewlis","sequence":"additional","affiliation":[{"name":"Centre for Orthopaedic and Trauma Research The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-8394","authenticated-orcid":false,"given":"Egon","family":"Perilli","sequence":"additional","affiliation":[{"name":"Medical Device Research Institute, College of Science and Engineering Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05240.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"e_1_2_8_5_1","unstructured":"American Joint Replacement Registry (AJRR): 2019 Annual Report. Rosemont IL: American Academy of Orthopaedic Surgeons (AAOS); 2019."},{"key":"e_1_2_8_6_1","unstructured":"National Joint Registry.16th Annual Report 2019: National Joint Registry for England Wales Northern Ireland and the Isle of Man;2019.\u00a0https:\/\/reports.njrcentre.org.uk\/. Accessed November 18 2020."},{"key":"e_1_2_8_7_1","unstructured":"Osteoarthritis. Canberra Australia: Australian Institute of Health and Wealfare (AIHW);\u00a02017.\u00a0https:\/\/www.aihw.gov.au\/reports\/arthritis-other-musculoskeletal-conditions\/osteoarthritis\/data. Accessed November 18 2020."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.2.188"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.7.617"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22515"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23474"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.02.028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.06.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.05.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.5.499"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115155"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60464-x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24208"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603515595501"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3313"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2018.07.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24022"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01495739708936692"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02509542"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00068-4"},{"key":"e_1_2_8_26_1","first-page":"75","article-title":"Micro\u2010CT examination of human bone: from biopsies towards the entire organ","volume":"48","author":"Perilli E","year":"2012","journal-title":"Ann Ist Super Sanita"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.12.003"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.01.137"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24245"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.10.009"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181956"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B6.12595"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00093-1"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-0033(98)00067-9"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.130"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201070"},{"key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/978-3-642-59373-4","volume-title":"Principles of Deformity Correction","author":"Paley D.","year":"2002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.07.007"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.07.015"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-009-0835-2"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/475684"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.1997.1340694.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01580.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738109350438"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00118-5"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00982-1"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453678208992844"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-2112-9"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.03.008"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24337"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23548"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2007.02.005"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.04.013"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1415-9"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.24914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:09:40Z","timestamp":1693325380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.24914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/jor.24914"],"URL":"https:\/\/doi.org\/10.1002\/jor.24914","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,25]]},"assertion":[{"value":"2020-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}