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Vancomycin\u2010loaded microcomposite implants were fabricated by incorporating drug\u2010loaded microparticles comprised of mesoporous silica into commonly employed polymethylmethacrylate (PMMA) bone cement, to yield a final drug loading of 10% w\/w. In vitro release kinetics at 37\u00b0C were monitored by reverse\u2010phase high\u2010performance liquid chromatography, and compared to the release kinetics of current therapy implants consisting of drug alone incorporated at 10% w\/w directly into PMMA bone cement. Results demonstrated a sevenfold improvement in the elution profile of microcomposite systems over current therapy implants. In vivo delivery of vancomycin to bone from microcomposite implants (70% of payload) was significantly higher than that from current therapy implants (approx. 22% of payload) and maintained significantly higher bone concentrations for up to 2 weeks duration. The elastic modulus showed no statistical difference between microcomposite implants and current standard therapy implants before drug elution, and maintenance of acceptable strength of microcomposite implants postdrug elution. These results demonstrate that we have developed a novel microcomposite spacer that will release continuously high antibiotic concentrations over a prolonged period of time, offering the possibility to eliminate infection and avoid the emergence of new resistant bacterial strains, while maintaining the requisite mechanical properties for proper space maintenance and joint fixation.<\/jats:p>","DOI":"10.1002\/jor.24919","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T11:20:41Z","timestamp":1606044041000},"page":"365-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Novel microcomposite implant for the controlled delivery of antibiotics in the treatment of osteomyelitis following total joint replacement"],"prefix":"10.1002","volume":"39","author":[{"given":"Serkan","family":"Inceoglu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Loma Linda University School of Medicine  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Botimer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Loma Linda University School of Medicine  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4029-8879","authenticated-orcid":false,"given":"Victoria K.","family":"Maskiewicz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Loma Linda University School of Pharmacy  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2016.03.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-19-00332"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(00)00520-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198870100-00015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164700317362280"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00003086-198312000-00014","article-title":"Total hip joint arthroplasty with gentamicin\u2010impregnated cement. 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