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Nacey Fellowship"],"award-info":[{"award-number":["James F. Nacey Fellowship"]}],"id":[{"id":"10.13039\/100009687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001388","name":"Wenner-Gren Foundation","doi-asserted-by":"publisher","award":["Gr. 9310"],"award-info":[{"award-number":["Gr. 9310"]}],"id":[{"id":"10.13039\/100001388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epigenetic factors, such as DNA methylation, play an influential role in the development of the degenerative joint disease osteoarthritis (OA). These molecular mechanisms have been heavily studied in humans, and although OA affects several other animals in addition to humans, few efforts have taken an evolutionary perspective. This study explores the evolution of OA epigenetics by assessing the relationship between DNA methylation variation and knee OA development in baboons (\n                    <jats:italic>Papio<\/jats:italic>\n                    spp.) and by comparing these findings to human OA epigenetic associations. Genome\u2010wide DNA methylation patterns were identified in bone and cartilage of the right distal femora from 56 pedigreed, adult baboons (28 with and 28 without knee OA) using the Illumina Infinium MethylationEPIC BeadChip. Several significantly differentially methylated positions (DMPs) and regions were found between tissue types. Substantial OA\u2010related differential methylation was also identified in cartilage, but not in bone, suggesting that cartilage epigenetics may be more influential in OA than bone epigenetics. Additionally, some genes containing OA\u2010related DMPs overlap with and display methylation patterns similar to those previously identified in human OA, revealing a mixture of evolutionarily conserved and divergent OA\u2010related methylation patterns in primates. Overall, these findings reinforce the current etiological perspectives of OA and enhance our evolutionary understanding of epigenetic mechanisms associated with OA. This study further establishes baboons as a valuable nonhuman primate model of OA, and continued investigations in baboons will help to disentangle the molecular mechanisms contributing to OA and their evolutionary histories.\n                  <\/jats:p>","DOI":"10.1002\/jor.24957","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T07:06:01Z","timestamp":1608102361000},"page":"2260-2269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["An evolutionary perspective of DNA methylation patterns in skeletal tissues using a baboon model of osteoarthritis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3482-7511","authenticated-orcid":false,"given":"Genevieve","family":"Housman","sequence":"first","affiliation":[{"name":"School of Human Evolution and Social Change Arizona State University  Tempe Arizona USA"},{"name":"Center for Evolution and Medicine Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2033-8693","authenticated-orcid":false,"given":"Ellen E.","family":"Quillen","sequence":"additional","affiliation":[{"name":"Department of Genetics Texas Biomedical Research Institute  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-8314","authenticated-orcid":false,"given":"Anne C.","family":"Stone","sequence":"additional","affiliation":[{"name":"School of Human Evolution and Social Change Arizona State University  Tempe Arizona USA"},{"name":"Center for Evolution and Medicine Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60802-3"},{"key":"e_1_2_9_3_1","unstructured":"WHO.Chronic rheumatic conditions.https:\/\/www.who.int\/chp\/topics\/rheumatic\/en\/. Accessed November 12 \u00a02016."},{"key":"e_1_2_9_4_1","unstructured":"CDC. Arthritis. Osteoarthritis (OA).http:\/\/www.cdc.gov\/arthritis\/basics\/osteoarthritis.htm. 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