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These combat\u2010related wounds often leave survivors with life\u2010long disability and represent a significant impediment to the readiness of the fighting force. There are immense opportunities for the field of tissue engineering and regenerative medicine (TE\/RM) to address these musculoskeletal injuries through regeneration of damaged tissues as a means to restore limb functionality and improve quality of life for affected individuals. Indeed, investigators have made promising advancements in the treatment for these injuries by utilizing small and large preclinical animal models to validate therapeutic efficacy of next\u2010generation TE\/RM\u2010based technologies. Importantly, utilization of a comprehensive suite of functional outcome measures, particularly those designed to mimic data collected within the clinical setting, is critical for successful translation and implementation of these therapeutics. To that end, the objective of this review is to emphasize the clinical relevance and application of gait biomechanics as a functional outcome measure for preclinical research studies evaluating the efficacy of TE\/RM therapies to treat traumatic musculoskeletal injuries. Specifically, common musculoskeletal injuries sustained by service members\u2014including volumetric muscle loss, post\u2010traumatic osteoarthritis, and composite tissue injuries\u2014are examined as case examples to highlight the use of gait biomechanics as an outcome measure using small and large preclinical animal models.<\/jats:p>","DOI":"10.1002\/jor.24990","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T05:26:27Z","timestamp":1610947587000},"page":"1139-1151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gait biomechanics: A clinically relevant outcome measure for preclinical research of musculoskeletal trauma"],"prefix":"10.1002","volume":"39","author":[{"given":"Jessica M.","family":"Motherwell","sequence":"first","affiliation":[{"name":"DoD\u2010VA Extremity Trauma and Amputation Center of Excellence Bethesda Maryland USA"},{"name":"Department of Surgery Uniformed 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