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Exercise\u2010induced loading alters cartilage hydration and is detectable using quantitative magnetic resonance imaging (MRI), where <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> relaxation time (<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>) is influenced by cartilage collagen composition, fiber orientation, and changes in the extracellular matrix. This study characterized short\u2010term transient responses of healthy knee cartilage to running\u2010induced loading using bilateral scans and image registration. Eleven healthy female recreational runners (33.73\u2009\u00b1\u20094.22 years) and four healthy female controls (27.25\u2009\u00b1\u20091.38 years) were scanned on a 3T GE MRI scanner with quantitative 3D double\u2010echo in steady\u2010state before running over\u2010ground (runner group) or resting (control group) for 40\u2009min. Subjects were scanned immediately post\u2010activity at 5\u2010min\u00a0intervals for 60\u2009min. <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> times were calculated for femoral, tibial, and patellar cartilage at each time point and analyzed using a mixed\u2010effects model and Bonferroni post hoc. There were immediate decreases in\u00a0<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> (mean\u2009\u00b1\u2009<jats:italic>SEM<\/jats:italic>) post\u2010run in superficial femoral cartilage of at least 3.3%\u2009\u00b1\u20090.3% (<jats:italic>p<\/jats:italic>\u2009=\u2009.002) between baseline and Time 0 that remained for 25\u2009min, a decrease in superficial tibial cartilage <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> of 2.9%\u2009\u00b1\u20090.4% (<jats:italic>p<\/jats:italic>\u2009=\u2009.041) between baseline and Time 0, and a decrease in superficial patellar cartilage <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> of 3.6%\u2009\u00b1\u20090.3% (<jats:italic>p<\/jats:italic>\u2009=\u2009.020) 15\u2009min post\u2010run. There were decreases in the medial posterior region of superficial femoral cartilage <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> of at least 5.3\u2009\u00b1\u20090.2% (<jats:italic>p<\/jats:italic>\u2009=\u2009.022) within 5\u2009min\u00a0post\u2010run that remained at 60\u2009min post\u2010run.\u00a0These results increase understanding of transient responses of healthy cartilage to repetitive, exercise\u2010induced loading and establish preliminary recommendations for future definitive studies of cartilage response to running.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.24994","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T06:11:11Z","timestamp":1611382271000},"page":"2340-2352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Characterizing the transient response of knee cartilage to running: Decreases in cartilage <i>T<\/i><sub>2<\/sub> of female recreational runners"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3663-5799","authenticated-orcid":false,"given":"Hollis A.","family":"Crowder","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering Stanford University Stanford California USA"},{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6700-8424","authenticated-orcid":false,"given":"Valentina","family":"Mazzoli","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-9071","authenticated-orcid":false,"given":"Marianne S.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"},{"name":"Department of Bioengineering Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feliks","family":"Kogan","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"},{"name":"Department of Bioengineering Stanford University Stanford California USA"},{"name":"Department of Electrical Engineering Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Levenston","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Stanford University Stanford California USA"},{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry E.","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California 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