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However, mesenchymal stem\/stromal cells at the origin of these clinical results are heterogenous cell populations with limited cellular characterization. Here, two transgenic reporter mice were used to examine the differential effects of two precisely defined perivascular cell populations (Pdgfr\u03b1<jats:sup>+<\/jats:sup>\u2009and Pdgfr\u03b2<jats:sup>+<\/jats:sup>\u2009cells) from white adipose tissue for alleviation of OA. Perivascular mesenchymal cells were isolated from transgenic Pdgfr\u03b1\u2010and Pdgfr\u03b2\u2010CreER<jats:sup>T2<\/jats:sup> reporter animals and delivered as a one\u2010time intra\u2010articular dose to C57BL\/6J mice after destabilization of the medial meniscus (DMM). Both Pdgfr\u03b1<jats:sup>+<\/jats:sup>\u2009and Pdgfr\u03b2<jats:sup>+<\/jats:sup>\u2009cell preparations improved metrics of cartilage degradation and reduced markers of chondrocyte hypertrophy. While some similarities in cell distribution were identified within the synovial and perivascular spaces, injected Pdgfr\u03b1<jats:sup>+<\/jats:sup>\u2009cells remained in the superficial layers of articular cartilage, while Pdgfr\u03b2<jats:sup>+<\/jats:sup>\u2009cells were more widely dispersed. Pdgfr\u03b2<jats:sup>+<\/jats:sup>\u2009cell therapy prevented subchondral sclerosis induced by DMM, while Pdgfr\u03b1<jats:sup>+<\/jats:sup>\u2009cell therapy had no effect. In summary, while both cell therapies showed beneficial effects in the DMM model, important differences in cell incorporation, persistence, and subchondral sclerosis were identified.<\/jats:p>","DOI":"10.1002\/jor.24997","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T10:41:33Z","timestamp":1611916893000},"page":"2388-2397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Divergent effects of distinct perivascular cell subsets for intra\u2010articular cell therapy in posttraumatic osteoarthritis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-3413","authenticated-orcid":false,"given":"Ginny Ching\u2010Yun","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Pathology Johns Hopkins University  Baltimore Maryland 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