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To safely place transsacral implants, they must be completely intraosseous. However, standard radiographs and CT do not properly demonstrate the corridor's intricate configuration. Our goal was to facilitate the three\u2010dimensional assessment of transsacral corridors using artificial intelligence and the planning of transsacral implant positioning. In total, 100 pelvic CTs (49 women, mean age: 58.6\u2009\u00b1\u2009SD 14.8 years; 51 men, mean age: 60.7\u2009\u00b1\u2009SD 13 years) were used to compute a 3D statistical model of the pelvic ring. On the basis of morphologic features (=predictors) and principal components scores (=response), regression learners were interactively trained, validated, and tuned to predict\/sample personalized 3D pelvic models. They were matched via thin\u2010plate spline transformation to a series of 20 pelvic CTs with fragility fractures of the sacrum (18 women\u00a0and 2 men, age: 69\u20139.5 years, mean age: 78.65\u2009\u00b1\u2009SD 8.4 years). These models demonstrated the availability, dimension, cross\u2010section, and symmetry of transsacral corridors S1 and S2,\u00a0as well as the planned implant position, dimension, axes, and entry\u00a0and exit points.\u00a0The complete intraosseous pathway was controlled in CT reconstructions. We succeeded to establish a workflow determining transsacral corridors S1 and S2 using artificial intelligence and 3D statistical modeling.<\/jats:p>","DOI":"10.1002\/jor.25010","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T10:23:38Z","timestamp":1613384618000},"page":"2681-2692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Artificial intelligence and CT\u2010based 3D statistical modeling to assess transsacral corridors and plan implant positioning"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8173-4361","authenticated-orcid":false,"given":"Lukas","family":"Kamer","sequence":"first","affiliation":[{"name":"AO Research Institute Davos  Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-4416","authenticated-orcid":false,"given":"Hansrudi","family":"Noser","sequence":"additional","affiliation":[{"name":"AO Research Institute Davos  Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-0299","authenticated-orcid":false,"given":"Charlotte","family":"Arand","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology University Medical Center  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-0585","authenticated-orcid":false,"given":"Kristin","family":"Handrich","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology University Medical Center  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-3876","authenticated-orcid":false,"given":"Pol Maria","family":"Rommens","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology University Medical Center  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-1018","authenticated-orcid":false,"given":"Daniel","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology University Medical Center  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-012-0224-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-66572-6_2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2019.11.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318191ea01"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-015-0530-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.53454"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.08.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-014-0653-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23554"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3181e47fad"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-200302000-00002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2013.08.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-015-4327-x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2017.03.023"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-019-03204-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.19.01128"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.01.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2009.07.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-94878-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-009-9187-7"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318270f9e7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12928"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/10929088.2012.709278"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2013.06.023"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-006-0771-9"},{"key":"e_1_2_9_27_1","unstructured":"[Date unknown]. 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