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The objective of this study was to explore different conditions of limb loading that could influence the biomechanics of the Lisfranc joint in a validated computational model. A computational model was created using SolidWorks software to represent the bones and soft tissues of the lower leg and foot. The model was compared to a cadaveric study of healthy and injured Lisfranc joints. The model was then used to simulate weight\u2010bearing radiographs and evaluate how muscle activity and foot position impacted the diastasis of the Lisfranc joint, a key indicator used to diagnose Lisfranc injuries. The computational model was within one standard deviation of the cadaveric study in all measurements for the healthy and injured foot. When simulating weight\u2010bearing radiographs, the presence of muscle activity or inversion\/eversion resulted in less joint separation for the model with ligamentous Lisfranc injuries. While previous research has noted that weight\u2010bearing radiographs provide better conditions to assess Lisfranc injuries than nonweight\u2010bearing, this study suggests that in weight\u2010bearing radiographs both altering the position of the foot, possibly due to pain, and the active contraction of the extrinsic flexor muscles can obfuscate indications of a Lisfranc injury.<\/jats:p>","DOI":"10.1002\/jor.25013","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T10:57:00Z","timestamp":1614077820000},"page":"2725-2731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Computational analysis of the clinical presentation of a ligamentous Lisfranc injury"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3358-5175","authenticated-orcid":false,"given":"M. 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