{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:54:19Z","timestamp":1779317659215,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01\u2010HD087459"],"award-info":[{"award-number":["R01\u2010HD087459"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis development after ACL reconstruction (ACLR) is not well understood. Investigators have examined associations between knee biomechanical alterations and quantitative MRI (qMRI) variables, reflective of cartilage health, 12\u201360 months following ACLR; however, none have done so early after surgery. As part of an exploratory study, 45 individuals (age, 23\u2009\u00b1\u20097 years) underwent motion analysis during walking and qMRI 3 months after ACLR. For each limb, peak knee adduction moment (pKAM) and peak knee flexion moment (pKFM) were determined using inverse dynamics and peak medial compartment force\u00a0was calculated using a neuromusculoskeletal model. T<jats:sub>2<\/jats:sub> relaxation times in the medial compartment and linear regressions were used to determine the associations between gait variables and deep and superficial cartilage T<jats:sub>2<\/jats:sub> relaxation times in six regions. pKAM was positively associated with deep layer T<jats:sub>2<\/jats:sub> relaxation times within the femoral central and posterior regions when examined in the involved limb and from an interlimb difference perspective (involved limb\u2009\u2013\u2009uninvolved limb). After adjusting for age, the association between interlimb difference of pKAM and interlimb difference of deep layer T<jats:sub>2<\/jats:sub> relaxation times in the tibial central region became significant (<jats:italic>p<\/jats:italic>\u2009=\u2009.043). Interlimb difference of pKFM was negatively associated with interlimb difference of deep layer T<jats:sub>2<\/jats:sub> relaxation times within the femoral central and posterior regions. These associations suggest that degenerative pathways leading to osteoarthritis may be detectable as early as 3 months after reconstruction. Preventative therapeutic techniques may need to be employed early in the rehabilitation process to prevent cartilage degradation.<\/jats:p>","DOI":"10.1002\/jor.25043","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T15:17:33Z","timestamp":1617117453000},"page":"252-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Knee cartilage T<sub>2<\/sub> relaxation times 3 months after ACL reconstruction are associated with knee gait variables linked to knee osteoarthritis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-1029","authenticated-orcid":false,"given":"Jack R.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Neal","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmajeed","family":"Alfayyadh","sequence":"additional","affiliation":[{"name":"Biomechanics and Movement Science University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendra","family":"Lennon","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9361-3700","authenticated-orcid":false,"given":"Jacob J.","family":"Capin","sequence":"additional","affiliation":[{"name":"Biomechanics and Movement Science University of Delaware  Newark Delaware USA"},{"name":"Department of Physical Therapy University of Delaware  Newark Delaware USA"},{"name":"Physical Therapy Program, Department of Physical Medicine and Rehabilitation University of Colorado  Aurora Colorado USA"},{"name":"Eastern Colorado VA Geriatric Research Education and Clinical Center (GRECC)  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6003-3881","authenticated-orcid":false,"given":"Ashutosh","family":"Khandha","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Manal","sequence":"additional","affiliation":[{"name":"Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hollis G.","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Snyder\u2010Mackler","sequence":"additional","affiliation":[{"name":"Biomechanics and Movement Science University of Delaware  Newark Delaware USA"},{"name":"Department of Physical Therapy University of Delaware  Newark Delaware USA"},{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Delaware  Newark Delaware USA"},{"name":"Biomechanics and Movement Science University of Delaware  Newark Delaware USA"},{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512459638"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.32.2000241"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505279913"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.1.160032"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2012.08.017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/928301"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23261"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546507307396"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514526139"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10101006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(05)80017-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515608475"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-52.6.06"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2015-094797"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-016-0510-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37724"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.08.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20132"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22991"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.7.617"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.1.000051"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062-2050-52.4.05"},{"issue":"3","key":"e_1_2_7_24_1","first-page":"162","article-title":"Quantitative MRI techniques of cartilage composition","volume":"3","author":"Matzat SJ","year":"2013","journal-title":"Quant Imaging Med Surg"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1620233"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-861764"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.01.071"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170002"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-1117-2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22817"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517743969"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2014.06.005"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517723007"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1123\/jab.20.4.367"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4023457"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.06.019"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1150"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.05.010"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514532227"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.02.779"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(01)00036-7"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24757"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.4.203"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509350301"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518795137"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.25043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:07:55Z","timestamp":1693195675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.25043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/jor.25043"],"URL":"https:\/\/doi.org\/10.1002\/jor.25043","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,19]]},"assertion":[{"value":"2020-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}