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The specimens were imaged a second time after a freeze\/thaw cycle and then processed for histology. T1, T2, and T1\u03c1 measurements in the SOC, epiphyseal cartilage, articular cartilage, and metaphysis were compared between operated and control femoral heads using paired <jats:italic>t<\/jats:italic> tests. The effects of freeze\/thaw, T1\u03c1 spin\u2010lock frequency, and fat saturation were also investigated. Five piglets with histologically confirmed ischemic injury were quantitatively analyzed. T1\u03c1 was increased in the SOC (101\u2009\u00b1\u200915 vs. 73\u2009\u00b1\u200916 ms; <jats:italic>p<\/jats:italic>\u2009=\u20090.0026) and epiphyseal cartilage (84.9\u2009\u00b1\u20099.2 vs. 74.3\u2009\u00b1\u20093.6\u2009ms; <jats:italic>p<\/jats:italic>\u2009=\u20090.031) of the operated versus control femoral heads. T2 was also increased in the SOC (28.7\u2009\u00b1\u20092.0 vs. 22.7\u2009\u00b1\u20091.7; <jats:italic>p<\/jats:italic>\u2009=\u20090.0037) and epiphyseal cartilage (57.4\u2009\u00b1\u20094.7 vs. 49.0\u2009\u00b1\u20092.7; <jats:italic>p<\/jats:italic>\u2009=\u20090.0041). No changes in T1 were detected. The sensitivities of T1\u03c1 and T2 mapping in detecting ischemic injury were maintained after a freeze\/thaw cycle, and T1\u03c1 sensitivity was maintained after varying spin\u2010lock frequency and applying fat saturation. In conclusion, T1\u03c1 and T2 mapping are sensitive in detecting ischemic injury to the SOC and epiphyseal cartilage of the femoral head as early as 48\u2009h after ischemia induction.<\/jats:p>","DOI":"10.1002\/jor.25044","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T10:57:47Z","timestamp":1617188267000},"page":"484-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["T1\u03c1 and T2 mapping detect acute ischemic injury in a piglet model of Legg\u2013Calv\u00e9\u2013Perthes disease"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-7296","authenticated-orcid":false,"given":"Casey P.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota  St. Paul Minnesota USA"},{"name":"Center for Magnetic Resonance Research University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-389X","authenticated-orcid":false,"given":"Ferenc","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota  St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy S.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota  St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra R.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Minnesota  St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-2828","authenticated-orcid":false,"given":"\u0160tefan","family":"Zb\u00fd\u0148","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota  Minneapolis Minnesota USA"},{"name":"Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta M.","family":"Ellermann","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota  Minneapolis Minnesota USA"},{"name":"Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-4777","authenticated-orcid":false,"given":"Harry K. 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