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Sharpe Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["AT010326\u201007"],"award-info":[{"award-number":["AT010326\u201007"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Orofacial pain is among the most common chronic pain conditions and can result from temporomandibular disorders (TMDs) of the temporomandibular joint (TMJ). Matrix metalloproteinases (MMPs) drive degeneration of TMJ tissues and likely mediate pain in TMJ disorders given their role in nociception. However, few studies have assessed MMPs in the TMJ innervated tissues nor in the context of pain. This study defined the extent of MMP\u20101, MMP\u20109, and MMP\u20102 in TMJ tissues from patients undergoing total joint replacement (TJR) or arthroplasty discectomy for painful TMJ disorders. Protein expression was probed by Western blot in TMJ disc and capsular ligaments taken during TJR (<jats:italic>n<\/jats:italic>\u2009=\u20096) or discectomy (<jats:italic>n<\/jats:italic>\u2009=\u20093) for osteoarthritis or internal derangement in an IRB\u2010approved study. Pro\u2010 and active MMP\u20101, active MMP\u20109, and pro\u2010 and active MMP\u20102 are detectable. MMP\u20101 and MMP\u20109 correlate positively to each other (Kendall's <jats:italic>\u03c4<\/jats:italic>\u2009=\u20090.63;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u20090.01), strengthening the hypothesis that they are mechanistically related in regulatory cascades. Active MMP\u20101 and active MMP\u20109 correlate positively with self\u2010reported pain scores (<jats:italic>\u03c4<\/jats:italic>\u2009\u2265\u20090.51; <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.04), suggesting their involvement in peripheral nociception. Overall, neither MMPs nor pain correlate\u00a0with the functional vertical opening of the jaw. MMP\u20101 varies with the observed stage of degeneration during surgery (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Neither overall MMPs nor pain correlate\u00a0with the overall magnetic resonance imaging scores, corroborating the longstanding, but confounding, clinical observation that pain and radiological evidence of joint damage are not always related. Clinical significance: These findings suggest that MMPs mediate pain in innervated soft tissues and may be targets for diagnosing disease stage and treatments in painful TMJ disorders.<\/jats:p>","DOI":"10.1002\/jor.25048","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T11:16:40Z","timestamp":1617275800000},"page":"338-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["MMPs in tissues retrieved during surgery from patients with TMJ disorders relate to pain more than to radiological damage score"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3737-0596","authenticated-orcid":false,"given":"Meagan E.","family":"Ita","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabesh","family":"Ghimire","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Granquist","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of\u00a0Oral &amp; Maxillofacial Surgery University of Pennsylvania School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0414-0484","authenticated-orcid":false,"given":"Beth A.","family":"Winkelstein","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Neurosurgery University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research","author":"Institute of Medicine","year":"2011"},{"key":"e_1_2_8_3_1","volume-title":"Temporomandibular Disorders: Priorities for Research and Care","author":"National Academies of Sciences, Engineering, and Medicine","year":"2020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001384"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516653743"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720030701"},{"key":"e_1_2_8_8_1","first-page":"179","volume-title":"International Review of Neurobiology","author":"Sessle BJ","year":"2011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0802472"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.10.032"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.09.051"},{"key":"e_1_2_8_12_1","unstructured":"KusiakJW VeasleyC MaixnerW et al. 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