{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:34:24Z","timestamp":1792607664375,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study tests if differences exist in the severity of synovial fibrosis between patients undergoing total knee arthroplasty (TKA) for osteoarthritis (OA) to help explain disparate deficits in pre\u2010 and postoperative range of motion (ROM) between patient groups. 117 knee OA patients were grouped by women (<jats:italic>n<\/jats:italic>\u2009=\u200974) and men (<jats:italic>n<\/jats:italic>\u2009=\u200943) or those who self\u2010reported as Black (<jats:italic>n<\/jats:italic>\u2009=\u200948) or White (<jats:italic>n<\/jats:italic>\u2009=\u200969). ROM was measured pre\u2010 and post\u2010TKA. Condyles and synovium collected during TKA were scored histologically for OA severity and synovitis. Fibrosis was measured from picrosirius\u2010stained sections of the synovium. Data were analyzed using Mann\u2013Whitney, parametric, and Spearman's rho tests with alpha at 0.05. We found no significant differences between patient age, BMI, radiographic scores, or deformity type when grouped by sex or race, or between metrics or OA severity when grouped by sex. Notably, higher synovitis was measured in women (<jats:italic>p<\/jats:italic>\u2009=\u2009.039) than men. White patients had greater ROM before (<jats:italic>p<\/jats:italic>\u2009=\u20090.46) and after surgery (<jats:italic>p<\/jats:italic>\u2009=\u2009.021) relative to Black patients. Fibrosis, but not OA severity and synovitis scores, for the total patient sample negatively correlated with preoperative (<jats:italic>r<\/jats:italic>\n<jats:sub>s<\/jats:sub>\u2009=\u2009\u22120.330; <jats:italic>p<\/jats:italic>\u2009=\u2009.0003) but not postoperative (<jats:italic>r<jats:sub>s<\/jats:sub>\n<\/jats:italic>\u2009=\u2009\u22120.032; <jats:italic>p<\/jats:italic>\u2009=\u2009.7627) ROM. Black patients manifested more fibrosis than White patients (<jats:italic>p<\/jats:italic>\u2009=\u2009&lt;.0001), without significant differences between sexes. Statement of Clinical Significance: Coupled with histological scoring, measuring perioperative differences in synovial fibrosis against ROM may refine OA classification and justify the in\u2010depth preoperative assessment of the knee as a whole. Such individualized analyses could guide personalized strategies to relieve symptomatic OA when TKA is not readily accessible and promote equitable TKA outcomes.<\/jats:p>","DOI":"10.1002\/jor.25061","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T10:44:41Z","timestamp":1619693081000},"page":"584-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Differences in synovial fibrosis relative to range of motion in knee osteoarthritis patients"],"prefix":"10.1002","volume":"40","author":[{"given":"Sydney","family":"Hodgeson","sequence":"first","affiliation":[{"name":"School of Medicine Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Morphology and Imaging Core Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Simkin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Plakotaris","sequence":"additional","affiliation":[{"name":"Morphology and Imaging Core Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Dasa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-2133","authenticated-orcid":false,"given":"Luis","family":"Marrero","sequence":"additional","affiliation":[{"name":"Morphology and Imaging Core Louisiana State University Health Sciences Center  New Orleans Louisiana USA"},{"name":"Department of Orthopaedics Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy N","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.2.1820337"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.11.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.02.046"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev228"},{"key":"e_1_2_9_7_1","first-page":"633","article-title":"Subtyping of osteoarthritic synoviopathy","volume":"20","author":"Oehler S","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21373"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140079"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.067470"},{"key":"e_1_2_9_11_1","first-page":"87","article-title":"Stiffness after total knee arthroplasty","volume":"87","author":"Nelson CL","year":"2005","journal-title":"JBJS"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-018-4518-8"},{"key":"e_1_2_9_13_1","first-page":"3","volume-title":"The Role of Fibrosis in Osteoarthritis Progression. 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