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The purpose of this study was to quantify elution kinetics of six antibiotics (amikacin, meropenem, fosfomycin, minocycline, cefazolin, and dalbavancin) from a clinically relevant CaSO<jats:sub>4<\/jats:sub> bead model and compare elution and antimicrobial activity to the current clinical gold standards: vancomycin and tobramycin. Antibiotic\u2010loaded synthetic CaSO<jats:sub>4<\/jats:sub> beads were immersed in phosphate buffered saline and incubated at 37\u00b0C. Eluent was harvested at eight time points over 28 days. Antibiotic concentrations were measured by high performance liquid chromatography to quantify elution rates. CaSO<jats:sub>4<\/jats:sub> beads demonstrated burst release kinetics. Dalbavancin, cefazolin, and minocycline all demonstrated similar elution profiles to vancomycin. Amikacin and meropenem demonstrated favorable elution profiles and durations of above\u2010minimum inhibitory concentration when compared to tobramycin.<\/jats:p><jats:p><jats:bold>Clinical Significance:<\/jats:bold> This study provides important novel data regarding the utility of amikacin, meropenem and dalbavancin as alternative choices to place in CaSO<jats:sub>4<\/jats:sub> carriers when treating orthopaedic infections.<\/jats:p>","DOI":"10.1002\/jor.25135","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T08:01:36Z","timestamp":1625126496000},"page":"1143-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Identifying alternative antibiotics that elute from calcium sulfate beads for treatment of orthopedic infections"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-6322","authenticated-orcid":false,"given":"Ashley E.","family":"Levack","sequence":"first","affiliation":[{"name":"Orthopaedic Trauma Service Hospital for Special Surgery New York New York USA"},{"name":"Orthopaedic Surgery &amp; 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