{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:20:07Z","timestamp":1784290807756,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to determine the efficacy of highly concentrated tricalcium phosphate (TCP) biocomposite screws on local bone formation in a rabbit model of osteoporosis induced by bilateral ovariohysterectomy (OHE). Fourteen 24\u2010week\u2010old female New Zealand rabbits (weight, 3\u20133.5\u2009kg) were divided into two groups: (1) OHE and biodegradable poly(lactic\u2010co\u2010glycolic acid) (PLGA) without \u00df\u2013TCP plate or screw insertion (OHE\/Bio ScRew [BSR]) group and (2) OHE and biocomposite PLGA with highly concentrated \u00df\u2013TCP plate and screw insertion (OHE\/highly concentrated \u00df\u2013triCalcium phosphate [HCCP]). Both groups underwent bilateral OHE and had two different types of screws and plates inserted at the proximal tibia. Bilateral tibiae were extracted at 25 weeks post\u2010OHE. The extracted tibiae were scanned with ex vivo microcomputed tomography (micro\u2010CT). Parameters including bone mineral density (BMD), trabecular bone volume (BV\/TV), trabecular number (Tb.N), trabecular thickness (Tb. Th), and trabecular separation (Tb. Sp) were evaluated after staining the tibial samples with hematoxylin and eosin (H&amp;E) and Masson's trichrome. We then performed pathological assessments. Micro\u2010CT images revealed improved new bone formation near the implant in the OHE\/HCCP group with higher values of BMD, BV\/TV, and Tb.N but lower values of Tb. Th and Tb. Sp than the OHE\/BSR group. Analyses of H&amp;E and Masson's trichrome staining showed better new bone formation around the implant in the OHE\/HCCP group than in the OHE\/BSR group. The use of highly concentrated TCP biocomposite screw and plate might improve local bone formation and facilitate osteoconductivity in an osteoporotic rabbit model.<\/jats:p>","DOI":"10.1002\/jor.25171","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T14:40:55Z","timestamp":1629902455000},"page":"1321-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bone formation effect of highly concentrated tricalcium phosphate biocomposite screws in a rabbit osteoporosis model"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-0113","authenticated-orcid":false,"given":"Je Hoon","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Soonchunhyang University Bucheon Hospital Bucheon Republic of Korea"},{"name":"Laboratory of Stem Cell Therapy, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-8244","authenticated-orcid":false,"given":"Eun\u2010Sun","family":"Jin","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Therapy, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"},{"name":"Department of Internal Medicine Kyung Hee University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-0161","authenticated-orcid":false,"given":"Ji Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Therapy, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-4797","authenticated-orcid":false,"given":"JoongKee","family":"Min","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Therapy, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-7978","authenticated-orcid":false,"given":"Sang Ryong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Therapy, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"},{"name":"Department of Neurological Surgery, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-6503","authenticated-orcid":false,"given":"Minsu","family":"Lee","sequence":"additional","affiliation":[{"name":"OSTEONIC Co., Ltd. Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-3889","authenticated-orcid":false,"given":"Kyoung Hyo","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Therapy, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"},{"name":"Department of Rehabilitation Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.785"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.07.083"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21050"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ID.0000099750.26582.4B"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2009.12.026"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-005-2532-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0797-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00234-8"},{"key":"e_1_2_9_10_1","first-page":"391","article-title":"Bilateral ovario\u2010hysterectomy induced osteoporotic rabbit model","volume":"33","author":"Jin ES","year":"2019","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.625"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2003.08.016"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm034247a"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00215-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199722)38:2<105::AID-JBM4>3.0.CO;2-U"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-008-0528-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-008-0334-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2001.7797"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30341"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.05.010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200202000-00009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(05)70114-0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30793"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-006-1048-3"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.25171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T09:01:32Z","timestamp":1692954092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.25171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/jor.25171"],"URL":"https:\/\/doi.org\/10.1002\/jor.25171","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,14]]},"assertion":[{"value":"2020-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}