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Here, we show how biomechanical and biochemical degradation pathways can predict FCD loss using a patient\u2010specific finite element model of an ACL reconstructed knee joint exhibiting a chondral lesion. Biomechanical degradation was based on the excessive maximum shear strains that may result in cell apoptosis, while biochemical degradation was driven by the diffusion of pro\u2010inflammatory cytokines. We found that the biomechanical model was able to predict substantial localized FCD loss near the lesion and on the medial areas of the lateral tibial cartilage. In turn, the biochemical model predicted FCD loss all around the lesion and at intact areas; the highest FCD loss was at the cartilage\u2013synovial fluid\u2010interface and decreased toward\u00a0the deeper zones. Interestingly, simulating a downturn of an acute inflammatory response by reducing the cytokine concentration exponentially over time in synovial fluid led to a partial recovery of FCD content in the cartilage. Our novel numerical approach suggests that in vivo FCD loss can be estimated in injured cartilage following ACL injury and reconstruction. Our novel modeling platform can benefit the prediction of PTOA progression and the development of treatment interventions such as disease\u2010modifying drug testing and rehabilitation strategies.<\/jats:p>","DOI":"10.1002\/jor.25177","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T15:33:28Z","timestamp":1631892808000},"page":"1505-1522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Shear strain and inflammation\u2010induced fixed charge density loss in the knee joint cartilage following ACL injury and reconstruction: A computational study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-7937","authenticated-orcid":false,"given":"Gustavo A.","family":"Orozco","sequence":"first","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland  Kuopio Finland"},{"name":"Department of Biomedical Engineering Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-3083","authenticated-orcid":false,"given":"Atte S. 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