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Not only does this approach require anatomically sized and functional engineered cartilage, but the inflammatory environment within an arthritic joint may also inhibit chondrogenesis and induce degradation of native and engineered cartilage. Here, we present the culmination of multiple avenues of interdisciplinary research leading to the development and testing of bioartificial cartilage for tissue\u2010engineered resurfacing of the hip joint. The work is based on a novel three\u2010dimensional weaving technology that is infiltrated with specific bioinductive materials and\/or genetically\u2010engineered stem cells. A variety of design approaches have been tested in vitro, showing biomimetic cartilage\u2010like properties as well as the capability for long\u2010term tunable and inducible drug delivery. Importantly, these cartilage constructs have the potential to provide mechanical functionality immediately upon implantation, as they will need to replace a majority, if not the entire joint surface to restore function. To date, these approaches have shown excellent preclinical success in a variety of animal studies, including the resurfacing of a large osteochondral defect in the canine hip, and are now well\u2010poised for clinical translation.<\/jats:p>","DOI":"10.1002\/jor.25223","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T11:35:49Z","timestamp":1637667349000},"page":"1721-1734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Functional tissue engineering of articular cartilage for biological joint resurfacing\u2014The 2021 Elizabeth Winston Lanier Kappa Delta Award"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-0330","authenticated-orcid":false,"given":"Farshid","family":"Guilak","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University\u00a0in St. Louis St. Louis Missouri USA"},{"name":"Shriners Hospitals for Children \u2013 St. Louis St. Louis Missouri USA"},{"name":"Center of Regenerative Medicine, Washington University St. Louis Missouri USA"},{"name":"Cytex Therapeutics, Inc. Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-3989","authenticated-orcid":false,"given":"Bradley T.","family":"Estes","sequence":"additional","affiliation":[{"name":"Cytex Therapeutics, Inc. Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin T.","family":"Moutos","sequence":"additional","affiliation":[{"name":"Cytex Therapeutics, Inc. Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"GuilakF SettonLA KrausVB. Structure and function of articular cartilage. In: Garrett WE Speer KP Kirkendall DT eds.Principles and Practice of Orthopaedic Sports Medicine. 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