{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:47:37Z","timestamp":1773938857250,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016M3A9F1941984"],"award-info":[{"award-number":["2016M3A9F1941984"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017M3A9D8048711"],"award-info":[{"award-number":["2017M3A9D8048711"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation\u2010predominant osteoarthritis is an important clinical type of osteoarthritis, with synovitis suggested as its distinct pathophysiology. We investigated whether the synovium's mechanical properties in knees differed by osteoarthritis and other clinical parameters through retrospectively analyzing intra\u2010articular pressure\u2013volume characteristics. We analyzed 60 knees that were administered intra\u2010articular corticosteroids while undergoing pressure monitoring. McMurray's test, pain complaints at end\u2010range knee flexion, Kellgren\u2013Lawrence classification from standing anteroposterior radiographs, and suprapatellar effusion from ultrasound constituted clinical parameters. Pressure\u2013volume profiles\u2014phasic changes in pressure by volume infusion, the volume of Phase 1\u2014the potential volume of the synovial space, the pressure at 45\u2009ml infusion\u2014intra\u2010articular pressure at a standardized volume, and the slope of Phase 2\u2014synovial stiffness were compared with clinical parameters. All graphs were biphasic. Knees with suprapatellar effusion or radiologically definite osteoarthritis (Kellgren\u2013Lawrence grade\u2009\u22652), had a lower Phase 1 volume. Knees with definite radiographic osteoarthritis also showed higher pressures at 45\u2009ml and Phase 2 slopes (171.11\u2009\u00b1\u200994.35\u2009mmHg and 5.08\u2009\u00b1\u20093.07\u2009mmHg\/ml, respectively) than those without (101.88\u2009\u00b1\u200958.12\u2009mmHg and 2.84\u2009\u00b1\u20091.27\u2009mmHg\/ml, respectively). The Phase 2 slope was higher for knees with positive provocative tests than in those with negative provocative tests, although not statistically significant. The synovium stretched earlier in knees with effusion or radiologically definite osteoarthritis. Intra\u2010articular pressure and synovial stiffness were significantly higher in patients with radiologically definite osteoarthritis. The synovium's mechanical characteristics are altered by osteoarthritis of the knee joint. Intra\u2010articular pressure characteristics could be utilized for synovial evaluation clinically.<\/jats:p>","DOI":"10.1002\/jor.25236","type":"journal-article","created":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T02:25:00Z","timestamp":1639275900000},"page":"2015-2024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intra\u2010articular pressure characteristics of the knee joint: An exploratory study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-9722","authenticated-orcid":false,"given":"Jae H.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Kosin University College of Medicine Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-578X","authenticated-orcid":false,"given":"Keewon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5785-8110","authenticated-orcid":false,"given":"Sun G.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital Seoul Republic of Korea"},{"name":"Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Aging Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,11]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"784p","volume-title":"Delisa's Physical Medicine & Rehabilitation Principles and Practice","author":"Delisa JA","year":"2010"},{"key":"e_1_2_10_3_1","first-page":"1330","article-title":"Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis","volume":"28","author":"Hill CL","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.11.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1286-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.80"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0670-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11094"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1060-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901105010100"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.07.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20535"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.29.3.261"},{"issue":"3","key":"e_1_2_10_15_1","first-page":"1022","article-title":"Mechanisms of action of an intraarticular 2.5% polyacrylamide hydrogel (arthramid vet) in a goat model of osteoarthritis: preliminary observations","volume":"3","author":"Tnibar A","year":"2017","journal-title":"SM J Biomed Eng"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"RobiK JakobN MatevzK MatjazV.The physiology of sports injuries and repair processes. 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