{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:47:20Z","timestamp":1789915640624,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["Grant # 1 I01 RX001208\u201001"],"award-info":[{"award-number":["Grant # 1 I01 RX001208\u201001"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osseointegration (OI) is being used for the direct skeletal attachment of prosthetic limbs using an intramedullary stem that extends percutaneously from the subject's residual limb. For this technology to be successful, bone ingrowth and remodeling around the implant must occur. Physicians need an effective way to assess bone remodeling to make informed treatment and rehabilitation decisions. Previous studies utilizing two\u2010dimensional imaging X\u2010ray as a tool to monitor bone\u2010remodeling around OI devices have limitations. This study describes methodology that was developed utilizing computed tomography (CT) imaging as a tool for analyzing bone remodeling around a percutaneous OI implant. Six transfemoral amputees implanted with a percutaneous osseointegrated prosthesis (POP) had CT scans taken of their residual femur at 6 and 52 weeks postoperatively. Three\u2010dimensional femoral models were processed using custom MATLAB script to collect cortical and medullary morphology measurements. Morphology data from 6\u2010\u00a0and 52\u2010week scans were compared to quantify bone remodeling around the POP implant. Fifty\u2010two weeks after implantation of the POP device, increases in cortical bone area and thickness were observed around the porous\u2010coated stem. Minimal changes were observed in the medullary canal parameters within the periprosthetic regions. This study successfully utilized CT imaging and three\u2010dimensional\u00a0modeling techniques to analyze longitudinal data of bone remodeling around a transfemoral percutaneous implant. These methods have the potential to be used as a clinical tool for evaluating orthopedic implants in vivo. Data collected suggests that the POP device achieved the desired bone remodeling around the porous\u2010coated region of the implanted stem.<\/jats:p>","DOI":"10.1002\/jor.25247","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T14:30:00Z","timestamp":1639578600000},"page":"2065-2075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of computer tomography imaging for analyzing bone remodeling around a percutaneous osseointegrated implant"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0855-4182","authenticated-orcid":false,"given":"Zakary","family":"Wankier","sequence":"first","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7743-4323","authenticated-orcid":false,"given":"Alex","family":"Drew","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Kubiak","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah USA"},{"name":"Department of Orthopedic Surgery University of Nevada Las Vegas Las Vegas Nevada USA"},{"name":"George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayant","family":"Agarwal","sequence":"additional","affiliation":[{"name":"George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City Utah USA"},{"name":"Division of Plastic Surgery Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-9803","authenticated-orcid":false,"given":"Sarina","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah USA"},{"name":"George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/03093648509164708"},{"issue":"2","key":"e_1_2_8_3_1","first-page":"161","article-title":"State\u2010of\u2010the\u2010art research in lower\u2010limb prosthetic biomechanics\u2010socket interface: a review","volume":"38","author":"Mak AF","year":"2001","journal-title":"J Rehabil Res Dev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00113-017-0331-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0009.8980"},{"key":"e_1_2_8_6_1","volume-title":"The Osseointegration Book: From Calvarium to Calcaneus","author":"Br\u00e5nemark P\u2010I","year":"2005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.17.00037"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"175","article-title":"Osseointegration in skeletal reconstruction and rehabilitation: a review","volume":"38","author":"Br\u00e5nemark R","year":"2001","journal-title":"J Rehabil Res Dev"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00806"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013508"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03093640701553922"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.19.00043"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.102B2.BJJ-2019-0697.R2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2020.01.017"},{"key":"e_1_2_8_15_1","first-page":"3","article-title":"Early experience with femoral and tibial bone\u2010anchored osseointegration prostheses","volume":"6","author":"Reif TJ","year":"2021","journal-title":"JB JS Open Access"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra053077"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000246541.41951.20"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.03.031"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2012.06.015"},{"issue":"7","key":"e_1_2_8_20_1","first-page":"1","article-title":"Osseointegrated prosthetic implants for people with lower\u2010limb amputation: a health technology assessment","volume":"19","author":"Ontario H","year":"2019","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24421"},{"key":"e_1_2_8_22_1","unstructured":"KubiakE AgarwalJ GillespieB BeckJP GilillandJ&SinclairSK. 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