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Knee joint contact characteristics have been thought to provide insights into the pathogenesis of knee OA; however, the cartilage contact characteristics in individuals with obesity have not been fully described. We conducted cartilage\u2010to\u2010cartilage contact analyses through high\u2010precision fluoroscopy imaging with subject\u2010specific magnetic resonance cartilage models. Twenty\u2010five individuals with obesity were recruited for this study, and previously published data consisted of eight nonobese individuals who were used as the comparator group. In both groups, knees were imaged by a dual fluoroscopic imaging system during treadmill walking, and the tibiofemoral cartilage contact locations were analyzed and described on the tibial plateau in the medial\u2212lateral (ML) and anterior\u2212posterior (AP) directions and on femoral condyle surfaces using contact angles in the sagittal plane and deviation angles in a plane perpendicular to the sagittal plane. On the medial tibial plateau, the ML contact locations in the individuals with obesity were located more medially than in the nonobese group throughout the stance phase. The medial plateau AP contact locations in individuals with obesity showed a different pattern compared with the nonobese group. The ML contact excursions on the medial plateau in the individuals with obesity were larger than in the nonobese group. These findings suggest that obesity affects the contact location mainly in the medial compartment, which explains, in part, the high prevalence of medial knee OA in the obese population.<\/jats:p>","DOI":"10.1002\/jor.25288","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T10:34:28Z","timestamp":1643106868000},"page":"2480-2487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cartilage contact characteristics of the knee during gait in individuals with obesity"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2744-1570","authenticated-orcid":false,"given":"Jing\u2010Sheng","family":"Li","sequence":"first","affiliation":[{"name":"College of Health and Rehabilitation Sciences: Sargent College Boston University Boston Massachusetts USA"},{"name":"Rheumatology Section Boston University School of Medicine Boston Massachusetts USA"},{"name":"Orthopaedic Bioengineering Research Center Newton\u2010Wellesley Hospital Newton Massachusetts USA"},{"name":"Department of Mechanical Engineering University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-2987","authenticated-orcid":false,"given":"Tsung\u2010Yuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Clancy","sequence":"additional","affiliation":[{"name":"Rheumatology Section Boston University School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9888-4902","authenticated-orcid":false,"given":"Cara L.","family":"Lewis","sequence":"additional","affiliation":[{"name":"College of Health and Rehabilitation 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