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Like in OA patients, gait patterns in rodent OA models shift to protect the injured limb during loading. However, unlike in OA patients, it is unknown how age affects gait changes in rodent OA models. In this study, gait compensations following meniscal injury in 3\u2010, 6\u2010, and 9\u2010month\u2010old rats were evaluated to examine age\u2010effects of OA\u2010related joint dysfunction. Rats 3, 6, and 9 months received medial collateral ligament transection plus medial meniscus transection (MCLT\u2009+\u2009MMT) surgery (<jats:italic>n<\/jats:italic>\u2009=\u20098\/age group) or a skin incision (<jats:italic>n<\/jats:italic>\u2009=\u20098\/age group). Postsurgery, rats underwent gait testing at 2, 4, 6, and 8 weeks. Postmortem, joints were processed for histology to assess cartilage damage. MCLT\u2009+\u2009MMT rats walked with reduced vertical loading in their injured limbs immediately after injury and throughout OA progression. Compared to sham\u2010operated limbs, 6\u2010\u00a0and 9\u2010month MCLT\u2009+\u2009MMT animals reduced loading in their injured limbs while 3\u2010month MCLT\u2009+\u2009MMT animals did not. MCLT\u2009+\u2009MMT rats also increased stance time on the injured limb compared to the contralateral limb. Additionally, for the MCLT\u2009+\u2009MMT animals, 6\u2010\u00a0and 9\u2010month animals had significantly worse cartilage damage compared to 3\u2010month animals. These data indicated age at injury onset affects how animals load the OA\u2010affected joint, with older animals developing gait compensations that more markedly reduce weight on the injured limb during walking.<\/jats:p>","DOI":"10.1002\/jor.25306","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T14:26:13Z","timestamp":1647267973000},"page":"2780-2791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Age alters gait compensations following meniscal injury in male rats"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4848-699X","authenticated-orcid":false,"given":"Kiara M.","family":"Chan","sequence":"first","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9078-3066","authenticated-orcid":false,"given":"Taylor D.","family":"Yeater","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-9148","authenticated-orcid":false,"given":"Kyle D.","family":"Allen","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"},{"name":"Department of Orthopedics and Sports Medicine University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_7_2_1","author":"Loeser RF","year":"2016","journal-title":"Nat Rev 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