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The goal of this study was to use a preclinical rat knee arthroplasty model to explore the changes in cement\u2212bone morphology and micromotion that occur with in vivo service. Narrow gaps between cement and bone under the tibial tray were present at early time points, and with even small magnitude micromotion, resulted in large micromotion\u2010to\u2010gap width ratios. These\u00a0data were\u00a0then used to develop models of fluid flow in the cement\u2212bone gaps to estimate potential for high fluid shear stress (FSS). Modeling results revealed supraphysiologic (&gt;4\u2009Pa) FSS were possible, particularly for cases in which eccentric loading applied to the implant and if the fluid in the gap consisted of marrow or synovial fluid. The early, high FSS environment, could cause fluid\u2010induced periprosthetic osteolysis locally, resulting in progressive loss of cement\u2212bone fixation.<\/jats:p>","DOI":"10.1002\/jor.25326","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T11:55:47Z","timestamp":1648209347000},"page":"94-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potential for supraphysiologic fluid shear stresses in a rat cemented knee replacement model"],"prefix":"10.1002","volume":"41","author":[{"given":"Mark A.","family":"Miller","sequence":"first","affiliation":[{"name":"SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Hardy","sequence":"additional","affiliation":[{"name":"SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7609-730X","authenticated-orcid":false,"given":"Megan E.","family":"Oest","sequence":"additional","affiliation":[{"name":"SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-0740","authenticated-orcid":false,"given":"Kenneth A.","family":"Mann","sequence":"additional","affiliation":[{"name":"SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199401000-00008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3248-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23586"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.04.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22634"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2012.06.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24390"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122091"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2010.504610"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23780"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27976"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-7949(00)00123-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0045-7825(86)90025-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-007-0085-y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-2010-0572"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/410972"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2013.10.036"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(87)90030-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.104014"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24977"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200010)52:1<210::AID-JBM27>3.0.CO;2-R"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.02.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(95)00058-P"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(94)90010-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2008.02.035"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.211"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.05.017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.6.930"},{"key":"e_1_2_7_30_1","first-page":"75","article-title":"Migration, particles, and fluid pressure. 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