{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:18:14Z","timestamp":1769095094918,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metal artifact reduction (MAR) has improved computed tomography (CT) imaging of total hip arthroplasty (THA) but the assessment of osteolysis and implant to bone contact relies on the accurate depiction of bone defects, cancellous bone, and cement. This study evaluates the impact of available single and dual\u2010energy protocols on periprosthetic tissue characterization in a cadaveric phantom. Bilateral THA was performed on a fresh frozen cadaveric pelvis with simulated osteolytic cavities. CT acquisitions with projection\u2010based\u00a0MAR and noise equivalence were performed using single energy 140\u2009kVp, single energy 150\u2009kVp with 0.6\u2009mm tin filtration, and dual\u2010energy at 100\/150\u2009kVp with 0.6\u2009mm tin filtration, from which simulated energies were extracted. Image subtraction, segmentation, region of interest histograms, and line profiles were used to characterize tissue density and separation. Tissue densities were heavily dependent on the energy profile of the protocol. Cancellous bone ranged from 182\u00a0to 45\u2009HU and cement from 1012\u00a0to 131\u2009HU using 140\u2009kVp compared to dual\u2010energy with weighted high energy tube, respectively. Spectral separation between cancellous bone, osteolytic defect, and cement was reduced for all protocols compared with 140\u2009kVp. Spectral overlap was most severe using dual\u2010energy with heavily weighted high\u2010energy tubes. Dual\u2010energy algorithms reduced trabecular contrast within the cancellous bone and cortical edge response. Although\u00a0the dual\u2010energy acquisition has been proposed as an additive to projection\u2010based MAR techniques in THA, reduced density and contrast in clinically relevant periprosthetic tissue compared to 140\u2009kVp single energy may limit its use in characterizing periprosthetic tissues.<\/jats:p>","DOI":"10.1002\/jor.25391","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T14:29:30Z","timestamp":1654180170000},"page":"657-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of computed tomography metal artifact reduction protocol on periprosthetic tissue characterization after total hip arthroplasty:\u00a0A cadaveric study"],"prefix":"10.1002","volume":"41","author":[{"given":"Andrew","family":"Dwyer","sequence":"first","affiliation":[{"name":"Clinical &amp; Research Imaging Centre, South Australian Health &amp; Medical Research Institute  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-2110","authenticated-orcid":false,"given":"Mishelle","family":"Korlaet","sequence":"additional","affiliation":[{"name":"Clinical &amp; Research Imaging Centre, South Australian Health &amp; Medical Research Institute  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-5238","authenticated-orcid":false,"given":"Stuart A.","family":"Callary","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Centre for Orthopedic and Trauma Research, The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-7533","authenticated-orcid":false,"given":"Thomas","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Centre for Orthopedic and Trauma Research, The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Smitham","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Centre for Orthopedic and Trauma Research, The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucian B.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Centre for Orthopedic and Trauma Research, The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","volume-title":"Hip, Knee & ShoulderArthroplasty: 2020 Annual Report, Adelaide","author":"Australian Orthopaedic Association National Joint Replacement Registry 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