{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:14:46Z","timestamp":1772032486991,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:00:00Z","timestamp":1659225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>LBX1<\/jats:italic> is a gene located near a single\u2010nucleotide polymorphism, rs11190870, which is highly associated with susceptibility to adolescent idiopathic scoliosis. However, the potential involvement of LBX1 in the etiology of this spinal deformity has not been elucidated. In this study, we aimed to determine whether the lack of LBX1 in skeletal muscle results in spinal deformities in mice. We generated mutant mice in which the <jats:italic>Lbx1<\/jats:italic> allele was conditionally excised under the control of a human muscle actin promoter. Mice lacking LBX1 from the skeletal muscle were fertile and available. The mutant mice had hypoplastic forelimbs and weighed less than control animals, but otherwise, there were no overt anomalies. The mice did not exhibit a scoliosis\u2010like spinal deformity; however, they developed moderate kyphosis as they grew old. These observations indicated that LBX1 is involved in limb development and potentially in the maintenance of spinal curvature\/alignment in mice.<\/jats:p>","DOI":"10.1002\/jor.25417","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T09:44:56Z","timestamp":1658310296000},"page":"884-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Abrogation of LBX1 in skeletal muscle results in hypoplastic limbs and progressive kyphosis in mice"],"prefix":"10.1002","volume":"41","author":[{"given":"Yusuke","family":"Matsuhashi","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7063-9609","authenticated-orcid":false,"given":"Keisuke","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Keio University School of Medicine Shinjuku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1796-1380","authenticated-orcid":false,"given":"Hideaki","family":"Imabayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Saiseikai Central Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naobumi","family":"Hosogane","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kyorin University Mitaka Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Keio University School of Medicine Shinjuku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morio","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Keio University School of Medicine Shinjuku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Defense Medical College Tokorozawa Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199912150-00006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181891751"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920208783884874"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197355050-00006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199709010-00014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.974"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(95)00450-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.614984"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.2.437"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/130970"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/13843"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.2.413"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20739"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.6.546"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.03.014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01357.2003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014136"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2012.11"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-012-2532-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-102067"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002280"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002413"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.08.025"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.24.7174"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.011668"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005802"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-012-2465-y"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-018-0095-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00459"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15122613"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2019.06.014"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003409"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420641"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.25417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:34:16Z","timestamp":1692729256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.25417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,31]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/jor.25417"],"URL":"https:\/\/doi.org\/10.1002\/jor.25417","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,31]]},"assertion":[{"value":"2022-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}