{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:03:55Z","timestamp":1769187835805,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cryopreserved bone allografts(CBA) are susceptible to infection, nonunion, and late stress fracture. Although\u00a0surgical revascularization by intramedullary implantation of an arteriovenous bundle (AV bundle) generates a neoangiogenic blood supply, there is potential for vascular ingrowth\u2010mediated bone resorption to weaken the graft. For this reason, we have evaluated changes in CBA mechanical properties of structural tibial allografts with and without surgically induced angiogenesis. Cryopreserved tibia bone allografts were transplanted to reconstruct a 3.5\u2009cm segmental tibial defect in 16 Yucatan mini pigs. Surgical revascularization was performed in half by implantation of a cranial tibial AV\u00a0bundle, (revascularization group). A control group of identical size had a ligated AV bundle implanted, (ligated group). At 20 weeks micro\u2010computed tomography (CT) measured bone mineral density (BMD) as well as bone union. Reference point indentation (RPI) compared cortex material properties, and axial compression determined the allotransplant compressive modulus. Seven of eight\u00a0tibiae in the angiogenesis group were healed at both junction points at 20 weeks. Only four\u00a0of eight\u00a0tibiae healed in the ligated control group. There was no significant difference between the revascularization and ligated control groups in BMD\u00a0and axial compression test. Similarly, RPI parameters were statistically equal. In paired comparisons with contralateral tibias, however, some RPI values were significantly worse in the ligated control group tibiae. This study demonstrates no adverse effect of surgical angiogenesis on cryopreserved structural bone allograft biomechanical properties in a large animal orthotopic segmental tibial defect model. These data suggest the potential value of surgical angiogenesis in clinical limb\u2010sparing reconstructive surgery.<\/jats:p>","DOI":"10.1002\/jor.25422","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T07:18:20Z","timestamp":1658819900000},"page":"815-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of surgical revascularization on the mechanical properties of cryopreserved bone allograft in a porcine tibia model"],"prefix":"10.1002","volume":"41","author":[{"given":"Noortje","family":"Visser","sequence":"first","affiliation":[{"name":"Microvascular Research Laboratory, Department of Orthopedic Surgery Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Plastic and Reconstructive Surgery, Amsterdam UMC University of Amsterdam  Amsterdam The 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