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To mitigate radiation damage, we recently observed a dose\u2010dependent response of high\u2010cycle fatigue behavior of human cortical bone from 0 to 25\u2009kGy, with lower doses exhibiting logarithmically longer fatigue lives. The objectives of this study were as follows: (1) to determine whether fracture toughness, work\u2010to\u2010fracture, and fatigue crack propagation resistance of human cortical bone are also radiation dose\u2010dependent, and (2) to determine the associations of radiation dose and a Raman biomarker for collagen disorder with fracture properties. Compact tension specimens were machined from two donor femoral pairs and allocated to four treatment groups: 0 (unirradiated control), 10, 17.5, and 25\u2009kGy. Fracture toughness specimens were monotonically loaded to failure and the critical stress intensity factor (<jats:italic>K<\/jats:italic><jats:sub>C<\/jats:sub>) was determined. Work\u2010to\u2010fracture was calculated from the load versus displacement integral up to fracture. Fatigue crack propagation specimens were cyclically loaded under constant room\u2010temperature irrigation and fatigue crack growth rate (<jats:italic>da<\/jats:italic>\/<jats:italic>dN<\/jats:italic>) and cyclic stress intensity (\u2206<jats:italic>K<\/jats:italic>) were calculated. Fracture toughness, work\u2010to\u2010fracture, and fatigue crack propagation resistance decreased 18%, 33%, and 15\u2010fold from 0 to 25\u2009kGy, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Radiation dose was more predictive of fracture properties than collagen disorder. These findings support that quasi\u2010static and fatigue fracture properties of cortical bone are radiation dose\u2010dependent within this dose range. The structural alterations arising from irradiation that cause these losses in fracture resistance remain to be elucidated.<\/jats:p>","DOI":"10.1002\/jor.25424","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T05:53:55Z","timestamp":1660197235000},"page":"823-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fatigue crack propagation and fracture toughness of cortical bone are radiation dose\u2010dependent"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-5866","authenticated-orcid":false,"given":"Dylan B.","family":"Crocker","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Case Western Reserve University Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L. 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