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However, many aspects of this therapy are poorly understood causing treatments to lack uniform effectiveness and reproducibility, which is in part a consequence of several inherent limitations to using bacteriophages to treat PJI. Herein, these limitations are discussed as are additional translational research that needs to be conducted to advance this therapeutic. These include determining if bacteria causing PJIs are polyclonal, consequences of bacteriophage attachment receptor phenotypic variations and ramifications of bacteriophage activity when bacteria interact with in vivo macromolecules. Only with the realization of the current limitations and subsequent knowledge gained from translational research will the potential of bacteriophages to reduce the morbidity and mortality in PJI be fully elucidated.<\/jats:p>","DOI":"10.1002\/jor.25432","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T02:48:40Z","timestamp":1661741320000},"page":"1097-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Bacteriophage therapy for periprosthetic joint infections: Current limitations and research needed to advance this therapeutic"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4977-0968","authenticated-orcid":false,"given":"James B.","family":"Doub","sequence":"first","affiliation":[{"name":"Division of Clinical Care and Research, Institute of Human Virology University of Maryland School of Medicine Baltimore Maryland 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