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Approximately 23% of these patients developed lasting \u201clong\u2010haul\u201d COVID symptoms, including fatigue, joint pain, and systemic hyperinflammation. However, the direct clinical impact of SARS\u2010CoV\u20102 infection on the skeletal system including bone and joint health has not been determined. Utilizing a humanized mouse model of COVID\u201019, this study provides the first direct evidence that SARS\u2010CoV\u20102 infection leads to acute bone loss, increased osteoclast number, and thinner growth plates. This bone loss could decrease whole\u2010bone mechanical strength and increase the risk of fragility fractures, particularly in older patients, while thinner growth plates may create growth disturbances in younger patients. Evaluating skeletal health in patients that have recovered from COVID\u201019 will be crucial to identify at\u2010risk populations and develop effective countermeasures.<\/jats:p>","DOI":"10.1002\/jor.25537","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T07:18:02Z","timestamp":1677136682000},"page":"1945-1952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Acute bone loss following SARS\u2010CoV\u20102 infection in mice"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-4224","authenticated-orcid":false,"given":"Anne K.","family":"Haudenschild","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery University of California Davis Health Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0105-6458","authenticated-orcid":false,"given":"Blaine A.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California Davis Health Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California Davis Health Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-6612","authenticated-orcid":false,"given":"Erin E.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology University of California Davis School of Veterinary Medicine  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Meissa Vaccines Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Meissa Vaccines Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Fyhrie","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California Davis Health Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper H. 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