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The conservative brace treatment aims to limit the deformity's progression until the end of skeletal growth. This study's objective was to develop a patient\u2010specific finite element model (FEM) simulating immediate in\u2010brace (IB) correction and subsequent growth modulation over 2 years of treatment. Thirty\u2010five retrospective AIS cases with documented correction over 2 years were analyzed. For each case, a patient\u2010specific FEM was built and IB correction was simulated. Vertebral growth and its modulation were modeled using simulated pressures on epiphyseal vertebral growth plates, including a compliance factor representing the recorded brace wear. The simulated Cobb angles, thoracic kyphosis, lumbar lordosis, and apical vertebral rotation were compared with the actual measurements immediately IB and out\u2010of\u2010brace (OOB) at the 2\u2010year follow\u2010up. Treatment outcomes according to simulated compliance scenarios of no brace\u2010wear versus full brace\u2010wear were also computed. The average immediate IB difference between the simulated and actual Cobb angle was 4.9\u00b0 (main thoracic [MT]) and 3.7\u00b0 (thoraco\u2010lumbar\/lumbar [TL\/L]). Two\u2010year OOB, it was 5.6\u00b0 (MT) and 5.4\u00b0 (TL\/L). The no brace\u2010wear and full brace\u2010wear compliance scenarios resulted respectively in 15\/35 (43%) and 31\/35 (89%) simulated spine deformities progressing by &lt;5\u00b0 over 2 years of treatment. Clinical significance: the FEM's ability to simulate the final correction with an accuracy on the order of the radiological measurements\u2019 interoperator reproducibility, combined with its sensitivity to brace\u2010wear compliance, provides confidence in the model's predictions for a comparative context of use like improving a brace's design before its application.<\/jats:p>","DOI":"10.1002\/jor.25553","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T03:11:21Z","timestamp":1678936281000},"page":"2065-2074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Finite element simulation of growth modulation during brace treatment of adolescent idiopathic scoliosis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-5631","authenticated-orcid":false,"given":"Aymeric","family":"Guy","sequence":"first","affiliation":[{"name":"Polytechnique Montreal Montreal Quebec Canada"},{"name":"Sainte\u2010Justine University Hospital Center Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2374-008X","authenticated-orcid":false,"given":"Carl\u2010\u00c9ric","family":"Aubin","sequence":"additional","affiliation":[{"name":"Polytechnique Montreal Montreal Quebec Canada"},{"name":"Sainte\u2010Justine University Hospital Center Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"87","article-title":"Actual evidence in the medical approach to adolescents with idiopathic scoliosis","volume":"50","author":"Negrini S","year":"2014","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199605150-00007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-007-0442-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000178819.90239.d0"},{"key":"e_1_2_7_6_1","first-page":"139","volume-title":"The Atlas of Spinal Orthotics. 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