{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:16:19Z","timestamp":1784024179921,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019PH026"],"award-info":[{"award-number":["ZR2019PH026"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH094"],"award-info":[{"award-number":["ZR2020MH094"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis (OA), a late\u2010stage complication of developmental dysplasia of the hip (DDH), is a key factor leading to further degeneration of joint function. Studies have shown that Sestrin2 (SESN2) is a positive regulator in protecting articular cartilage from degradation. However, the regulatory effects of SESN2 on DDH\u2010OA and its upstream regulators remain obscure. Here, we first identified that the expression of SESN2 significantly decreased in the cartilage of DDH\u2010OA samples, with an expression trend negatively correlated with OA severity. Using RNA sequencing, we identified that the upregulation of miR\u201034a\u20105p may be an important factor for the decrease in SESN2 expression. Further exploring the regulation mechanism of miR\u201034a\u20105p\/SESN2 is of great significance for understanding the mechanism of DDH occurrence and development. Mechanistically, we showed that miR\u201034a\u20105p could significantly inhibit the expression of SESN2, thereby promoting the activity of the mTOR signaling pathway. We also found that miR\u201034a\u20105p significantly inhibited SESN2\u2010induced autophagy, thereby suppressing the proliferation and migration of chondrocytes. We further validated that knocking down miR\u201034a\u20105p in vivo resulted in a significant increase in SESN2 expression and autophagy activity in DDH\u2010OA cartilage. Our study suggests that miR\u201034a\u20105p is a negative regulator of DDH\u2010OA, and may provide a new target for the prevention of DDH\u2010OA.<\/jats:p>","DOI":"10.1002\/jor.25639","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T07:41:27Z","timestamp":1686296487000},"page":"66-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["MicroRNA\u201034a\u20105p promotes the progression of osteoarthritis secondary to developmental dysplasia of the hip by restraining SESN2\u2010induced autophagy"],"prefix":"10.1002","volume":"42","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"},{"name":"School of Rehabilitation Medicine Capital Medical University Beijing China"},{"name":"Department of Neurological Rehabilitation, Beijing Bo'ai Hospital China Rehabilitation Research Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Weifang Medical University Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine the First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang 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