{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:22:00Z","timestamp":1783473720166,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>In this cross\u2010sectional study, we compared patellofemoral geometry in individuals with a youth\u2010sport\u2010related intra\u2010articular knee injury to uninjured individuals, and the association between patellofemoral geometry and magnetic resonance imaging (MRI)\u2010defined osteoarthritis (OA) features. In the Youth Prevention of Early OA (PrE\u2010OA) cohort, we assessed 10 patellofemoral geometry measures in individuals 3\u201310 years following injury compared with uninjured individuals of similar age, sex, and sport, using mixed effects linear regression. We also dichotomized geometry to identify extreme (&gt;1.96 standard deviations) features and assessed likelihood of having extreme values using Poisson regression. Finally, we evaluated the associations between patellofemoral geometry with MRI\u2010defined OA features using restricted cubic spline regression. Mean patellofemoral geometry did not differ substantially between groups. However, compared with uninjured individuals, injured individuals were more likely to have extremely large sulcus angle (prevalence ratio [PR] 3.9 [95% confidence interval, CI: 2.3, 6.6]), and shallow lateral trochlear inclination (PR 4.3 (1.1, 17.9)) and trochlear depth (PR 5.3 (1.6, 17.4)). In both groups, high bisect offset (PR 1.7 [1.3, 2.1]) and sulcus angle (PR 4.0 [2.3, 7.0]) were associated with cartilage lesion, and most geometry measures were associated with at least one structural feature, especially cartilage lesions and osteophytes. We observed no interaction between geometry and injury. Certain patellofemoral geometry features are correlated with higher prevalence of structural lesions compared with injury alone, 3\u201310 years following knee injury. Hypotheses generated in this study, once further evaluated, could contribute to identifying higher\u2010risk individuals who may benefit from targeted treatment aimed at preventing posttraumatic OA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.25640","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T07:34:27Z","timestamp":1686296067000},"page":"78-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patellofemoral joint geometry and osteoarthritis features 3\u201310 years after knee injury compared with uninjured knees"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-6052","authenticated-orcid":false,"given":"Erin M.","family":"Macri","sequence":"first","affiliation":[{"name":"Department Orthopaedics and Sports Medicine Erasmus University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department General Practice Erasmus University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Family Practice University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-4976","authenticated-orcid":false,"given":"Jackie L.","family":"Whittaker","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of British Columbia Vancouver Canada"},{"name":"Sport Injury Prevention Research Centre, Faculty of Kinesiology University of Calgary Calgary Canada"},{"name":"Arthritis Research Canada Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-100X","authenticated-orcid":false,"given":"Clodagh M.","family":"Toomey","sequence":"additional","affiliation":[{"name":"Sport Injury Prevention Research Centre, Faculty of Kinesiology University of Calgary Calgary Canada"},{"name":"School of Allied Health, Faculty of Education and Health Sciences University of Limerick Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-2297","authenticated-orcid":false,"given":"Jacob L.","family":"Jaremko","sequence":"additional","affiliation":[{"name":"Department Radiology and Diagnostic Imaging University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3784-8753","authenticated-orcid":false,"given":"Jean\u2010Michel","family":"Galarneau","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-0521","authenticated-orcid":false,"given":"Janet L.","family":"Ronsky","sequence":"additional","affiliation":[{"name":"Sport Injury Prevention Research Centre, Faculty of Kinesiology University of Calgary Calgary 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