{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:41:39Z","timestamp":1793346099387,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periprosthetic joint infections occur in about 2% of patients who undergo primary total joint arthroplasty, a procedure performed over 1 million times in the United States. The gold standard of treatment is a two\u2010stage revision. This study aimed to establish a two\u2010stage procedure in a preclinical small animal model (rat) to test and compare the efficacy of an antibiotic\u2010eluting material in managing infection. Joint replacement was simulated by transchondylarly implanting a polyethylene (PE) plug into the distal femur and a titanium screw in the proximal tibia. Methicillin\u2010sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> (MSSA) 10<jats:sup>8<\/jats:sup>\u2009CFU<jats:bold>\/<\/jats:bold>mL was injected into the tibial canal and the joint space before wound closure. The control groups were killed on postoperative day (POD) 18 (<jats:italic>n<\/jats:italic>\u2009=\u200912) and on POD 42 (<jats:italic>n<\/jats:italic>\u2009=\u20094) to assess both early and later\u2010stage outcomes in the control group. The test group underwent revision surgery on POD 18 for treatment using gentamicin\u2010eluting polyethylene (GPE, <jats:italic>n<\/jats:italic>\u2009=\u20094) and was observed until POD 42 to evaluate the efficacy of treatment. Our results showed that the bone loss for the treatment group receiving GPE was significantly less than that of the control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), which was supported by the histology images and an AI\u2010tool assisted infection rate evaluation. Gait metrics duty factor imbalance and hindlimb temporal symmetry were significantly different between the treatment and control groups on Day 42. This animal model was feasible for evaluating treatments for peri\u2010prosthetic joint infections (PJI) with a revision surgery and specifically that revision surgery and local antibiotic treatment largely hindered the peri\u2010prosthetic bone loss. Statement of clinical significance: This revision model of peri\u2010prosthetic infection has the potential of comparatively evaluating prophylaxis and treatment strategies and devices. Antibiotic\u2010eluting UHMWPE is devised as at tool in treating PJI while providing weight bearing and joint space preservation.<\/jats:p>","DOI":"10.1002\/jor.25681","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T10:21:16Z","timestamp":1692786076000},"page":"460-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The efficacy of antibiotic\u2010eluting material in a two\u2010stage model of periprosthetic joint infection"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2550-7954","authenticated-orcid":false,"given":"Yingfang","family":"Fan","sequence":"first","affiliation":[{"name":"Harris Orthopaedic Laboratory Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Orthopaedic Surgery Harvard Medical School Boston Massachusetts 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