{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:50:18Z","timestamp":1793908218887,"version":"4.8.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A carbon fiber\u2010reinforced polyetheretherketone (CFR\/PEEK) hip stem with a special antibiotic elution mechanism is under development to treat periprosthetic joint infection (PJI). The antibiotic elution characteristics of intramedullary implants were experimentally investigated, and the efficacy of revision surgery using a therapeutic stem in treating ovine PJI was examined. To evaluate elution characteristics, the intramedullary vancomycin\u2010loaded CFR\/PEEK cylindrical implants were inserted in the distal femur of nine sheep, and the vancomycin elution rate was measured at 2, 7, and 21 days. To evaluate therapeutic efficacy, the PJI model with <jats:italic>staphylococcus aureus<\/jats:italic> was attempted to create for five sheep. Moreover, the therapeutic vancomycin\u2010loaded CFR\/PEEK stem was implanted during one\u2010stage revision surgery. Three weeks after revision surgery, the treatment efficacy was evaluated based on bacterial cultures and wound findings. In addition, the vancomycin elution rate from the stem was measured. On average, the cylindrical implants eluted approximately 70% vancomycin in 21 days. Of the five sheep attempting to create a PJI model, three were successfully infected with <jats:italic>S. aureus<\/jats:italic> as intended for verification of treatment efficacy. In all three joints, negative bacterial cultures and no purulence were observed 3 weeks after revision surgery. The vancomycin elution rates from the stems were &gt;70%. Efficient elution of vancomycin was confirmed by the experimental implant inserted into the bone marrow and the stem in actual PJI treatment. Using a novel therapeutic stem with an antibiotic elution mechanism in one\u2010stage revision surgery, successful treatment was demonstrated in all <jats:italic>S. aureus<\/jats:italic>\u2010induced PJIs.<\/jats:p>","DOI":"10.1002\/jor.25691","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T15:48:20Z","timestamp":1695224900000},"page":"474-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic efficacy of vancomycin\u2010loaded carbon fiber\u2010reinforced polyetheretherketone hip stem for periprosthetic joint infection: A pilot study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-4633","authenticated-orcid":false,"given":"Ichiro","family":"Nakahara","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery National Hospital Organization Osaka Minami Medical Center Osaka 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