{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:11:59Z","timestamp":1785791519082,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell therapy has been explored as a new regenerative treatment for osteoarthritis in the field of regenerative medicine. However, the efficacy of stem cell transplantation from different sources for the treatment of knee osteoarthritis (KOA) remains controversial. This study integrates and evaluates the previously published data of stem cell transplantation for KOA to explore the curative effect of different stem cells. We conducted a meta\u2010analysis of randomized controlled trials on stem cell therapy for KOA. Measures of efficacy included Visual Analog Scale (VAS), Lequesne index, Lysholm Knee Scoring Scale (LKSS), and Western Ontario and McMaster University Osteoarthritis Index (WOMAC). Joint injury was evaluated through the Whole\u2010Organ Magnetic Resonance Imaging Score (WORMS) system. We analyzed 16 studies involving 875 KOA patients. The stem cell treatment showed significant VAS reduction from the third month onwards. Subgroup analysis suggested the most significant pain relief at different postoperative months came from adipose\u2010derived and umbilical cord\u2010derived stem cells. Autologous adipose tissue resulted in better pain alleviation compared with allogenic. However, autologous bone marrow stem cells did not show increased pain relief over allogeneic ones. Combination therapy (HA and\/or PRP) showed no effect. Autologous adipose\u2010derived stem cells demonstrate the most effective recovery of knee joint function. In WORMS assessment, there was no significant difference between the stem cell group and control. Stem cell transplantation proved safe and effective for KOA treatment. Different sources stem cells have a good effect on alleviating knee joint pain, restoring knee joint function, and minimizing patient trauma.<\/jats:p>","DOI":"10.1002\/jor.25724","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T11:14:36Z","timestamp":1700824476000},"page":"753-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of mesenchymal stromal cells transplantation on the outcomes of patients with knee osteoarthritis: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-3335","authenticated-orcid":false,"given":"Rong\u2010hui","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Orthopedics Jiujiang First People's Hospital Jiujiang City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010guo","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Jiujiang First People's Hospital Jiujiang City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Stomatology Affiliated Stomatological Hospital of Jiujiang College Jiujiang City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Jiujiang College Jiujiang City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Long","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Affiliated Hospital of Jiujiang College Jiujiang City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2021_695"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520946364"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-019-09583-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2525-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2020.10.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0000000000000191"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1242-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2021.08.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2019.06.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-021-05243-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001274R"},{"key":"e_1_2_8_13_1","first-page":"9163","article-title":"Intraarticular 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