{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:20:30Z","timestamp":1770229230432,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010975","name":"Pediatric Orthopaedic Society of North America","doi-asserted-by":"publisher","award":["673076"],"award-info":[{"award-number":["673076"]}],"id":[{"id":"10.13039\/100010975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteonecrosis of the femoral head (ONFH) is a devastating bone disease that is caused by a disruption of blood supply leading to necrotic cell death. Clinically, it was found that obesity has a high prevalence with ONFH. However, it remains unclear how obesity may directly affect tissue regeneration and bone healing in osteonecrosis (ON). The purpose of this study is to investigate the effects of obesity and weight loss (WL) on ON healing. In this study, we induced obesity and WL in an established surgery\u2010induced ON mouse model via feeding a high\u2010fat diet (HFD) and altering the diet respectively. All mice received a surgical induction of ON of distal femoral epiphysis at the age of 12 weeks. HFD was switched to normal diet (ND) after ON surgery to induce WL. Mouse body weight was recorded weekly. Mouse body composition was scanned by DEXA (Dual\u2010energy X\u2010ray absorptiometry) right after sacrifice at the age of 16 weeks. The distal femoral bone samples were fixed and embedded for histology such as H&amp;E, immunohistochemistry, and TRAP staining. In this study, we found that HFD\u2010induced obesity impaired revascularization and bone remodeling showing decreased vessel areas and reduced osteoblast and osteoclast numbers. WL could rescue obesity\u2010induced bone healing defects. Our study is the first to test the direct effects of obesity and WL on ON bone healing. We believe our work may provide new concepts for osteonecrosis treatment in obese patients.<\/jats:p>","DOI":"10.1002\/jor.25728","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:17:34Z","timestamp":1700245054000},"page":"811-820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Obesity impairs revascularization and bone healing in a mouse model of osteonecrosis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-9529","authenticated-orcid":false,"given":"Zhuo","family":"Deng","sequence":"first","affiliation":[{"name":"Center for Excellence in Hip Scottish Rite for Children Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Aguirre\u2010Flores","sequence":"additional","affiliation":[{"name":"Center for Excellence in Hip Scottish Rite for Children Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-4777","authenticated-orcid":false,"given":"Harry K. W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Excellence in Hip Scottish Rite for Children Dallas Texas USA"},{"name":"Department of Orthopaedic Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3361-6015","authenticated-orcid":false,"given":"Yinshi","family":"Ren","sequence":"additional","affiliation":[{"name":"Center for Excellence in Hip Scottish Rite for Children Dallas Texas USA"},{"name":"Department of Orthopaedic Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Osteonecrosis of the femoral head: etiology, investigations, and management","volume":"10","author":"Baig SA","year":"2018","journal-title":"Cureus"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.4.180036"},{"key":"e_1_2_8_4_1","volume-title":"Avascular Necrosis","author":"Matthews AH","year":"2022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-199801000-00005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12857"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ortho.IJOrtho_292_16"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i8.590"},{"key":"e_1_2_8_9_1","first-page":"51","article-title":"Hip replacement in femoral head osteonecrosis: current concepts","volume":"12","author":"Scaglione M","year":"2015","journal-title":"Clin Cases Miner Bone Metab"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/601763"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.33724b"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.6458"},{"key":"e_1_2_8_13_1","volume-title":"Environmental Factors and Obesity","author":"Yadav HM","year":"2022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.615375"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316101"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.168017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116215"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-6-30"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-018-0018-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4172-6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20733"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2018.10.003"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23402"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4191"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.10.010"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.08.011"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz002"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.10.011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2019.12.004"},{"issue":"1","key":"e_1_2_8_31_1","first-page":"S18","article-title":"Core decompression of the femoral head for avascular necrosis: indications and results","volume":"38","author":"Steinberg ME","year":"1995","journal-title":"Can J Surg"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-019-1359-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.624903"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.2001.2368"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01049-8"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.778078"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.622035"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T10:09:16Z","timestamp":1711620556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.25728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,29]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/jor.25728"],"URL":"https:\/\/doi.org\/10.1002\/jor.25728","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,29]]},"assertion":[{"value":"2023-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}