{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:48:29Z","timestamp":1778626109908,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","award":["2019\u2010314"],"award-info":[{"award-number":["2019\u2010314"]}],"id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009459","name":"Hvidovre Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis is a prevalent and severe disease. Involvement of the trapeziometacarpal joint is common and can lead to both pain and disability. Genetics are known to affect the risk of osteoarthritis, but it remains unclear how genetics affect disease trajectories. In this study, we investigated whether the genetic associations of trapeziometacarpal osteoarthritis (rhizarthrosis) vary with the need for surgical treatment. The study was conducted as a case\u2010control genome\u2010wide association study using individuals from the Copenhagen Hospital Biobank pain and degenerative musculoskeletal disease study and the Danish Blood Donor Study (<jats:italic>N<\/jats:italic>\u2009=\u2009208,342). We identified patients diagnosed with rhizarthrosis and grouped them by treatment status, resulting in two case groups: surgical (<jats:italic>N<\/jats:italic>\u2009=\u20091083) and nonsurgical (<jats:italic>N<\/jats:italic>\u2009=\u20091888). The case groups were tested against osteoarthritis\u2010free controls in two genome\u2010wide association studies. We then compared variants suggestive of association (<jats:italic>p<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22126<\/jats:sup>) in either of these analyses directly between the treatment groups (surgical vs. nonsurgical rhizarthrosis). We identified 10 variants suggestive of association with either surgical (seven variants) or nonsurgical (three variants) rhizarthrosis. None of the variants reached nominal significance in the opposite treatment group (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.14), and all 10 variants were significantly different between the treatment groups at a false discovery rate of 5%. These results suggest possible differences in the genetic associations of rhizarthrosis depending on surgical treatment. Clinical significance: Uncovering genetic differences between clinically distinct patient groups can reveal biological determinants of disease trajectories.<\/jats:p>","DOI":"10.1002\/jor.25753","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T08:01:13Z","timestamp":1706083273000},"page":"1001-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetics may affect the risk of undergoing surgery for rhizarthrosis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4219-5374","authenticated-orcid":false,"given":"Cecilie","family":"Henkel","sequence":"first","affiliation":[{"name":"Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"DBDS Genomic Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine, Health Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisse R.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Clinical Academic Group: Research OsteoArthritis Denmark (CAG ROAD) Greater Copenhagen Health Science Partners Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Clinical Academic Group: Research OsteoArthritis Denmark (CAG ROAD) Greater Copenhagen Health Science Partners Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Clinical Immunology Zealand University Hospital K\u00f8ge K\u00f8ge Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Troelsen","sequence":"additional","affiliation":[{"name":"Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Clinical Academic Group: Research OsteoArthritis Denmark (CAG ROAD) Greater Copenhagen Health Science Partners Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen 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