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But little is known about how genetic factors influence rotator cuff tear patient characteristics at presentation. We collected saliva samples for genotyping from atraumatic rotator cuff tear patients. We examined nine single nucleotide polymorphisms (SNPs) associated with cuff tears in prior literature. We estimated associations of SNP dosage with (1) age at tear diagnosis, (2) bilateral atraumatic tear prevalence, and (3) tear size. Linear regression was used to estimate associations with diagnosis age adjusted for sex and principal components. Logistic regression and ordinal logistic regression were used to estimate associations with bilateral tear prevalence and tear size category, respectively, adjusting for age, sex, and principal components. Of 344 eligible patients, 336 provided sufficient samples for genotyping. Median age at tear diagnosis was 61, 22% (<jats:italic>N<\/jats:italic>\u2009=\u200974) had bilateral atraumatic tears, and 9% (<jats:italic>N<\/jats:italic>\u2009=\u200929) had massive tears. SNP rs13107325 in the <jats:italic>SLC39A8<\/jats:italic> gene and rs11850957 in the <jats:italic>STXBP6<\/jats:italic> gene were associated with younger diagnosis age even after accounting for multiple comparisons (rs13107325: \u22124 years, 95% CI\u2009=\u2009\u22126.5, \u22121.4; rs11850957: \u22122.7 years, 95% CI\u2009=\u2009\u22124.3, \u22121.1). No other significant associations were observed with diagnosis age, tear size, or bilateral tear prevalence. <jats:italic>SLC39A8<\/jats:italic> encodes a Mn transporter. <jats:italic>STXBP6<\/jats:italic> may play a role in inflammatory responses by altering phagocytosis and antigen presentation of monocytes and macrophages. Further research is needed to determine if genetic markers can be used alongside patient characteristics to aid in identifying optimal surgical repair candidates.<\/jats:p>","DOI":"10.1002\/jor.25754","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T16:04:23Z","timestamp":1701533063000},"page":"934-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors associated with genetic markers for rotator cuff disease in patients with atraumatic rotator cuff tears"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-0201","authenticated-orcid":false,"given":"Elizabeth L.","family":"Yanik","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Saccone","sequence":"additional","affiliation":[{"name":"Department of Genetics Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander W.","family":"Aleem","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Zmistowski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne 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