{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T04:51:41Z","timestamp":1740113501988,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Developmental dysplasia of the hip (DDH) is a developmental disorder characterized by acetabular dysplasia leading to early osteoarthritis. This study examines the role of endoplasmic reticulum stress (ERS) in chondrocyte apoptosis and cartilage degeneration within a DDH model. In the rat model of DDH, created using a swaddling technique, significant deformities in the femoral head and acetabulum were observed, alongside an upregulation of matrix metalloproteinase\u201013 in acetabular cartilage. We also noted increased levels of apoptosis and ERS\u2010related factors in the acetabular cartilage of DDH models. Additionally, rat chondrocytes exposed to high\u2010magnitude cyclic tensile strain (CTS, 1\u2009Hz, 10% equibiaxial strain) in vitro exhibited elevated ERS and increased apoptosis. Importantly, treatment with the ERS inhibitor 4\u2010phenylbutyric acid effectively suppressed apoptosis induced by CTS in chondrocytes. Our findings suggest that ERS contributes to the upregulation of apoptosis\u2010related factors in chondrocytes within the DDH model, indicating the potential of ERS modulation as a therapeutic approach for DDH\u2010related cartilage degeneration.<\/jats:p>","DOI":"10.1002\/jor.25763","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T11:39:38Z","timestamp":1701689978000},"page":"993-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of endoplasmic reticulum stress on chondrocyte apoptosis in rat model of DDH"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0133-2085","authenticated-orcid":false,"given":"Yaxier","family":"Nijiati","sequence":"first","affiliation":[{"name":"Department of Pediatric Orthopaedics, National Children's Medical Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopaedics, National Children's Medical Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopaedics, National Children's Medical Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopaedics, National Children's Medical Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixue","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopaedics, National Children's Medical Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopaedics, National Children's Medical Center Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.4.190006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56040153"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2014.07.012"},{"key":"e_1_2_5_5_1","first-page":"313","article-title":"Surgical treatment of developmental dysplasia of the hip","volume":"63","author":"Wenger DR","year":"2014","journal-title":"Instr Course Lect"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.5301\/hipint.5000571"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1998.0162"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57431-x"},{"key":"e_1_2_5_9_1","first-page":"3873","article-title":"Cellular and molecular changes to chondrocytes in an in vitro model of developmental dysplasia of the hip\u2011an experimental model of DDH with swaddling position","volume":"18","author":"Ning B","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2016.150557"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2005.07.003"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300604"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161125943"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03730.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122146"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12644"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030665"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.09.021"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161025152423"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201100055"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.028"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013177"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2738"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.07.005"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/415092a"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.03.009"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1606"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25005"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.10.019"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119816"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-011-1315-6"},{"key":"e_1_2_5_32_1","first-page":"1369","article-title":"Early articular cartilage degeneration in a developmental dislocation of the hip model results from activation of \u03b2\u2010catenin","volume":"7","author":"Ning B","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2018.03.001"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325818810636"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.07.094"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501069200"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2755"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T01:13:04Z","timestamp":1712884384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.25763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/jor.25763"],"URL":"https:\/\/doi.org\/10.1002\/jor.25763","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"type":"print","value":"0736-0266"},{"type":"electronic","value":"1554-527X"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"2023-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}