{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:26:51Z","timestamp":1783700811172,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH093"],"award-info":[{"award-number":["ZR2020MH093"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postmenopausal osteoporosis (PMOP) affects hundreds of millions of elderly women worldwide. The imbalance between osteoblast\u2010mediated bone formation and osteoclast\u2010mediated bone resorption is the key factor in the progression of PMOP. Recently, exosomal circular RNAs\u00a0have been considered as critical regulators in physiological and pathological progress. However, their roles in PMOP still require further exploration. Herein, we identified that the expression of exosomal circFAM63B significantly increased in PMOP patients and is closely related to bone density. We further demonstrated that circFAM63B inhibits osteogenic differentiation of bone marrow stromal cells and bone formation in ovariectomy mice by using a combination of in vitro and in vivo experiment strategies. Mechanistically, circFAM63B promotes HMGA2 expression by inhibiting miR\u2010578, thereby suppressing bone repair. Our study proved that exosomal circFAM63B suppresses the bone regeneration of PMOP by regulating the miR\u2010578\/HMGA2 axis, which may provide new insights into the pathogenesis and development of PMOP. Knocking down exosomal circFAM63B could be regarded as a new strategy for the treatment of PMOP.<\/jats:p>","DOI":"10.1002\/jor.25776","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T05:49:25Z","timestamp":1703742565000},"page":"1244-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal osteoporosis via regulating miR\u2010578\/HMGA2 axis"],"prefix":"10.1002","volume":"42","author":[{"given":"Feng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Spine Surgery the First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery the First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery the First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery the First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery the First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichi","family":"Fang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Department of Orthopedic Surgery Division of Hand&amp; Foot and Microvascular Surgery, the First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People's Hospital) Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Department of Orthopedic Surgery Division of Hand&amp; Foot and Microvascular Surgery, the First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People's Hospital) Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery the First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital) Weifang China"},{"name":"Clinical College of Orthopedics Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6312-4674","authenticated-orcid":false,"given":"Gaoyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Department of Orthopedic Surgery Division of Hand&amp; Foot and Microvascular Surgery, the First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People's Hospital) Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32112-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02646-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32167-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301570"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115654"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.2023s130"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad496"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2023.07.022"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-023-01309-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00866-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2923"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528376"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.64533"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.06.026"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0269-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16906"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.57887"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-99-1443-2_11"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06114-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01525-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0251-y"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02214-y"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00208-x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103334"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092073"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.05.036"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1994"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109844"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530323666230224120457"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00261-0"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1041-z"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0221-6"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0158-7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00856-2"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14059"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/15257770.2022.2155300"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1719"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-02043-4"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.122"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13059"},{"issue":"11","key":"e_1_2_8_44_1","first-page":"3311","article-title":"Mir\u201098 reduces the expression of HMGA2 and promotes osteogenic differentiation of mesenchymal stem cells","volume":"22","author":"Gao XL","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T09:17:22Z","timestamp":1714209442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.25776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,15]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jor.25776"],"URL":"https:\/\/doi.org\/10.1002\/jor.25776","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,15]]},"assertion":[{"value":"2023-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}