{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:44:42Z","timestamp":1787813082433,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although platelet\u2010rich plasma (PRP)\u00a0has been widely used regardless of the severity of muscle strain, there have been very few basic studies in which its effects on muscle injury were examined by using models that accurately mimic the clinical muscle strain injury process. Therefore, the aim of this study was to confirm by physiological and structural analyses whether PRP purified by a general preparation method has a muscle healing effect on muscle damage caused by eccentric contraction (ECC).\u00a0Male Wistar rats were subjected to muscle injury induced by ECC in bilateral plantar flexor muscles using electrical stimulation and an automatically dorsiflexing footplate. The rats were randomly assigned to three groups by type of injection: phosphate\u2010buffered saline (PBS),\u00a0leukocyte\u2010poor PRP (LP\u2010PRP),\u00a0or leukocyte\u2010rich PRP (LR\u2010PRP)\u00a0injection into gastrocnemius muscles three times at weekly intervals. The platelet concentrations of the LP\u2010PRP\u00a0and LR\u2010PRP\u00a0were three to five times higher than that of whole blood. The recovery process of torque strength in the plantar flexor muscle, signal changes in MRI images, and histological evaluation 3 weeks after injury showed no obvious differences among the three groups, and every muscle recovered well from the injury without marked fibrosis. The results that neither LP\u2010PRP\u00a0nor LR\u2010PRP\u00a0was found to accelerate healing of muscle injuries suggested that conventional preparation and use of PRP for simple muscle injuries caused by muscle strain should be carefully considered, and further basic research using models that accurately mimic clinical practice should be carried out to determine the optimal use of PRP.<\/jats:p>","DOI":"10.1002\/jor.25784","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:39:28Z","timestamp":1705451968000},"page":"1190-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Platelet\u2010rich plasma does not accelerate the healing of damaged muscle following muscle 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