{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T02:53:38Z","timestamp":1776394418305,"version":"3.51.2"},"reference-count":82,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Production of metal debris from implant wear and corrosion processes is now a well understood occurrence following hip arthroplasty. Evidence has shown that metal ions can enter the bloodstream and travel to distant organs including the brain, and in extreme cases, can induce sensorial and neurological diseases. Our objective was tosimultaneously analyze brain anatomy and physiology in patients with long\u2010term and well\u2010functioning implants. Included were subjects who had received total hip or hip resurfacing arthroplastywith an implantation time of a minimum of 7 years (<jats:italic>n<\/jats:italic>\u2009=\u200928) and age\u2010 and sex\u2010matched controls (<jats:italic>n<\/jats:italic>\u2009=\u200932). Blood samples were obtained to measure ion concentrations of cobalt and chromium, and the Montreal Cognitive Assessment was performed. 3T MRI brain scans were completed with an MPRAGE sequence for ROI segmentation and multiecho gradient echo sequences to generate QSM and R2* maps. Mean QSM and R2* values were recorded for five deep brain and four middle and cortical brain structures on both hemispheres: pallidum, putamen, caudate, amygdala, hippocampus, anterior cingulate, inferior temporal, and cerebellum. No differences in QSM or R2* or cognition scores were found between both groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.6654). No correlation was found between susceptibility and blood ion levels for cobalt or chromium in any region of the brain. No correlation was found between blood ion levels and cognition scores.\u00a0Clinical significance: Results suggest that metal ions released by long\u2010term and well\u2010functioning implants do not affect brain integrity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.25785","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T15:10:40Z","timestamp":1705590640000},"page":"1292-1302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing brain integrity in patients with long\u2010term and well\u2010functioning metal\u2010based hip implants"],"prefix":"10.1002","volume":"42","author":[{"given":"Shahnaz","family":"Taleb","sequence":"first","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Imaging Group, Robarts Research Institute Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Varela\u2010Mattatall","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Imaging Group, Robarts Research Institute Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbigail","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Surgery, London Health Sciences Centre Division of Orthopaedic Surgery London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Haast","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Imaging Group, Robarts Research Institute Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali R.","family":"Khan","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Imaging Group, Robarts Research Institute Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Kalia","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Schulich School of Medicine &amp; Dentistry,\u00a0Division of Musculoskeletal Imaging Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Surgery, London Health Sciences Centre Division of Orthopaedic Surgery London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Surgery, London Health Sciences Centre Division of Orthopaedic Surgery London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi S.","family":"Menon","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Imaging Group, Robarts Research Institute Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent A.","family":"Lanting","sequence":"additional","affiliation":[{"name":"Department of Surgery, London Health Sciences Centre Division of Orthopaedic Surgery London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3911-3171","authenticated-orcid":false,"given":"Matthew G.","family":"Teeter","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Imaging Group, Robarts Research Institute Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics10020059"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.3.296"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2019.1636993"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04648-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S360643"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3922"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.CC.15.00063"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2011.tb03151.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.3262.2013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1174-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1329-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR-21-0098"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00176"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24768"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.18383\/j.tom.2015.00136"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.210054"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.597854"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24976"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22928"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24951"},{"issue":"10","key":"e_1_2_8_22_1","first-page":"1267","article-title":"Hemisphere, gender and age\u2010related effects on iron deposition in deep gray matter revealed by quantitative susceptibility mapping","volume":"28","author":"Gong NJ","year":"2015","journal-title":"NBM"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.067"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118477"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20181016"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117611"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25420"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2014.09.004"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122640"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25569"},{"key":"e_1_2_8_31_1","unstructured":"KuurstraA. qsm_sstv.2020. Accessed November 13 2022.https:\/\/github.com\/AlanKuurstra\/qsm_sstv"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2017.05.015"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00125"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327111414280"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.57B3.289"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/PTS.0000000000000220"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.01.063"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25693"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-9589-5_3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020718718550"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-016-9952-2"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rmr.0000245459.82782.e4"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.077"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4260"},{"issue":"6","key":"e_1_2_8_45_1","first-page":"3778","article-title":"Evaluation of abnormal iron distribution in specific regions in the brains of patients with Parkinson's disease using quantitative susceptibility mapping and R2* mapping","volume":"19","author":"Cheng Q","year":"2020","journal-title":"Exp Ther Med"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1958.tb12607.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106877"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.126378"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118371"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.049"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-87"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.02.008"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050706"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522081399"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.618435"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522081399"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.01568"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.329"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911177107"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.045"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.08.050"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10110941"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B1.36712"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B8.27626"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.11.045"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2013.01.005"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.O.00201"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-1040(04)70100-2"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/690620"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2013.857024"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2013.779633"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.944977"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.670244"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2016.1214274"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2008.07.017"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21638"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21902"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000159"},{"issue":"4","key":"e_1_2_8_79_1","article-title":"Reproducibility of R2 * and quantitative susceptibility mapping (QSM) reconstruction methods in the basal ganglia of healthy subjects","volume":"30","author":"Santin MD","year":"2017","journal-title":"NBM"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24943"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2019.04.12"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.127"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26369"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T09:17:48Z","timestamp":1714209468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.25785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jor.25785"],"URL":"https:\/\/doi.org\/10.1002\/jor.25785","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,18]]},"assertion":[{"value":"2023-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}