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While bisphosphonates can reduce bone loss and risk of fracture, these drugs are systemic, rely on long\u2010term use, and patient compliance is low. Recombinant human bone morphogenetic protein\u20102 (BMP\u20102) is an FDA\u2010approved protein that can offer a more targeted therapeutic than systemic treatments. DWIVA is a peptide sequence corresponding to the wrist epitope of BMP\u20102, and DWIVA\u2010functionalized hydrogels feature osteoinductive propertiesin vitro and in vivo. This study reports that self\u2010forming DWIVA\u2010functionalized hydrogels injected into the intramedullary canal of rat femurs induce a local increase in trabecular bone in as little as 2 weeks. Increases in bone volume, trabecular thickness, and trabeculae count from DWIVA\u2010laden hydrogels persist for at least 4 weeks, and the inclusion of mesenchymal stem cells (MSCs) significantly enhances the development of mineralized bone. Histological analysis of decalcified femurs also shows that hydrogel injections containing DWIVA peptide and MSCs stimulate unmineralized bone tissue formation and induce an increased count of osteoblasts and osteoclasts at the injection site after 4 weeks. Overall, the MSC\u2010laden DWIVA\u00a0peptide\u2010functionalized hydrogels presented rapidly induce targeted bone formation and have the potential to form nascent bone within bones in jeopardy of an osteoporotic fracture such as the femur.<\/jats:p>","DOI":"10.1002\/jor.25798","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T13:04:28Z","timestamp":1707311068000},"page":"1599-1607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mesenchymal stem cells enhance targeted bone growth from injectable hydrogels with BMP\u20102 peptides"],"prefix":"10.1002","volume":"42","author":[{"given":"Stacy A.","family":"Love","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Rowan University Glassboro New Jersey USA"},{"name":"Department of Orthopaedic Surgery Cooper University Health Care Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirstene A.","family":"Gultian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Rowan University Glassboro New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umu S.","family":"Jalloh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Rowan University Glassboro New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Rowan University Glassboro New Jersey USA"},{"name":"Department of Surgery Cooper Medical School of Rowan University Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1533-0032","authenticated-orcid":false,"given":"Tae Won B.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Rowan University Glassboro New Jersey USA"},{"name":"Department of Orthopaedic Surgery Cooper University Health Care Camden New Jersey USA"},{"name":"Department of Orthopaedic Surgery Cooper Medical School of Rowan University Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-1552","authenticated-orcid":false,"given":"Sebasti\u00e1n L.","family":"Vega","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Rowan University Glassboro New Jersey USA"},{"name":"Department of Orthopaedic Surgery Cooper Medical School of Rowan University Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2016.048"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2269"},{"key":"e_1_2_7_4_1","first-page":"437","article-title":"Bone health and osteoporosis: a report of the surgeon general","volume":"87","author":"Rockville","year":"2004","journal-title":"US Heal. 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