{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:06:15Z","timestamp":1777561575515,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K09409"],"award-info":[{"award-number":["22K09409"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to investigate the relationship between superoxide dismutase 2\u2010related oxidative stress in the paraspinal muscles and spinal alignment, clinical skeletal muscle parameters, and mitochondrial function. Multifidus muscle samples from patients who underwent posterior lumbar surgery were analyzed. Patients with diseases affecting oxidative stress and spinal alignment were excluded. The superoxide dismutase 2 redox index was defined as the ratio of reactive oxygen species (superoxide) to antioxidant enzymes (superoxide dismutase 2) and was used as an index of oxidative stress. Patients were divided into two groups based on the superoxide dismutase 2 redox index. Spinal alignment, clinical skeletal muscle parameters, and succinic dehydrogenase (SDH) mean grayscale value were compared between the groups, with analyzes for both sexes. Multiple regression analyzes were used to adjust for the confounding effect of age on variables showing a significant difference between the two groups. Thirty\u2010five patients with lumbar degenerative diseases were included. No significant differences were observed between the two groups for any of the parameters in males; however, females with a higher superoxide dismutase 2 redox index had greater lumbar lordosis, lower grip strength, and higher SDH mean grayscale value than those with a lower index. Multiple regression analyzes revealed that the superoxide dismutase 2 redox index was an independent explanatory variable for lumbar lordosis, grip strength, and SDH mean grayscale value in female patients. In conclusion, superoxide dismutase 2\u2010related oxidative stress in the paraspinal muscles was associated with mitochondrial dysfunction and decreased grip strength in female lumbar degenerative disease patients.<\/jats:p>","DOI":"10.1002\/jor.25863","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T04:05:42Z","timestamp":1713845142000},"page":"2287-2295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decreased grip strength is associated with paraspinal muscular oxidative stress in female lumbar degenerative disease patients"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7778-4178","authenticated-orcid":false,"given":"Ryosuke","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Medicine for Orthopaedics and Motor Organ Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Orthopaedics Juntendo University School of Medicine Tokyo Japan"},{"name":"Spine and Spinal Cord Center Juntendo University Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Nojiri","sequence":"additional","affiliation":[{"name":"Department of Medicine for Orthopaedics and Motor Organ Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Orthopaedics Juntendo University School of Medicine Tokyo Japan"},{"name":"Spine and Spinal Cord Center Juntendo University Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukoh","family":"Ohara","sequence":"additional","affiliation":[{"name":"Spine and Spinal Cord Center Juntendo University Hospital Tokyo Japan"},{"name":"Department of Neurosurgery Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-0805","authenticated-orcid":false,"given":"Muneaki","family":"Ishijima","sequence":"additional","affiliation":[{"name":"Department of Medicine for Orthopaedics and Motor Organ Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Orthopaedics Juntendo University School of Medicine Tokyo Japan"},{"name":"Spine and Spinal Cord Center Juntendo University Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-012-2207-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000179086.30449.96"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001202"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz253"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.3.SPINE161011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jspd.2018.06.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13013-017-0116-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33867-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2733-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000004175"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-019-05904-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14670"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90800.2008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90281-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.03.011"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.000525"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.02.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09148"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602118200"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S158513"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31823e15e2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-018-5858-8"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92296-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2013.866040"},{"key":"e_1_2_7_29_1","first-page":"3071","article-title":"Clinical case study: spine modeling for minimum invasive spine surgeries (MISS) using rapid prototyping","volume":"226","author":"Chougule VN","year":"2018","journal-title":"Bone (CT)"},{"key":"e_1_2_7_30_1","article-title":"Tissue triage and freezing for models of skeletal muscle disease","volume":"15","author":"Meng H","year":"2014","journal-title":"J Vis Exp"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.01.028"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7598-3_32"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24472"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/5.4.420"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-3-18"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13998"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00024.2014"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP087007"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00230.2019"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-015-0033-y"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00014.2015"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-020-09883-x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158713"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00321.2016"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12933"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14417"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187765"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-017-5404-0"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.25863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T19:25:10Z","timestamp":1729193110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.25863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/jor.25863"],"URL":"https:\/\/doi.org\/10.1002\/jor.25863","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2023-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}