{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:28:27Z","timestamp":1790612907854,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Muscle weakness following anterior cruciate ligament reconstruction (ACLR) increases the risk of posttraumatic osteoarthritis (OA). However, focusing solely on muscle weakness overlooks other aspects like muscle composition, which could hinder strength recovery. Intramuscular fat is a non\u2010contractile element linked to joint degeneration in idiopathic OA, but its role post\u2010ACLR has not been thoroughly investigated. To bridge this gap, we aimed to characterize quadriceps volume and intramuscular fat in participants with ACLR (male\/female\u2009=\u200915\/9, age\u2009=\u200922.8\u2009\u00b1\u20093.6 years, body mass index [BMI]\u2009=\u200923.2\u2009\u00b1\u20091.9, time since surgery\u2009=\u20093.3\u2009\u00b1\u20090.9 years) and in controls (male\/female\u2009=\u200914\/10, age\u2009=\u200922.0\u2009\u00b1\u20093.1 years, BMI\u2009=\u200923.3\u2009\u00b1\u20092.6) while also exploring the associations between intramuscular fat and muscle volume with isometric strength. Linear mixed effects models assessed (I) muscle volume, (II) intramuscular fat, and (III) strength between limbs (ACLR vs. contralateral vs. control). Regression analyses were run to determine if intramuscular fat or volume were associated with quadriceps strength. The ACLR limb was 8%\u221211% smaller than the contralateral limb (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). No between\u2010limb differences in intramuscular fat were observed (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.091\u22120.997). Muscle volume but not intramuscular fat was associated with strength in the ACLR and control limbs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001\u22120.002). We demonstrate that intramuscular fat does not appear to be an additional source of quadriceps dysfunction following ACLR and that muscle size only explains some of the variance in muscle strength.\n                  <\/jats:p>","DOI":"10.1002\/jor.25910","type":"journal-article","created":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:23:47Z","timestamp":1717287827000},"page":"2485-2494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Beyond weakness: Exploring intramuscular fat and quadriceps atrophy in ACLR recovery"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-138X","authenticated-orcid":false,"given":"McKenzie S.","family":"White","sequence":"first","affiliation":[{"name":"School of Kinesiology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin 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