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A quantitative description of baseline STT joint morphometrics is needed to capture the variation of normal anatomy as well as to guide staging of osteoarthritis. Statistical shape modeling (SSM) techniques quantify variations in three\u2010dimensional shapes and relative positions. The objectives of this study are to describe the morphology of the STT joint using a multi\u2010domain SSM. We asked: (1) What are the dominant modes of variation that impact bone and articulation morphology at the STT joint, and (2) what are the morphometrics of SSM\u2010generated STT joints? Thirty adult participants were recruited to a computed tomography study of normal wrist imaging and biomechanics. Segmentations of the carpus were converted to three\u2010dimensional triangular surface meshes. A multi\u2010domain, particle\u2010based entropy system SSM was used to quantify variation in carpal bone shape and position as well as articulation morphology. Articular surface areas and interosseous proximity distributions were calculated between mesh vertex pairs on adjacent bones within distance (2.0\u2009mm) and surface\u2010normal angular (35\u00b0) thresholds. In the SSM, the first five modes of variation captured 76.2% of shape variation and contributed to factors such as bone scale, articular geometries, and carpal tilt. Median interosseous proximities\u2014a proxy for joint space\u2014were 1.39\u2009mm (scaphotrapezium), 1.42\u2009mm (scaphotrapezoid), and 0.61\u2009mm (trapeziotrapezoid). This study quantifies morphological and articular variations at the STT joint, presenting a range of normative anatomy. The range of estimated interosseous proximities may guide interpretation of imaging\u2010derived STT joint space.<\/jats:p>","DOI":"10.1002\/jor.25918","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T01:15:15Z","timestamp":1719969315000},"page":"2562-2574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Morphology of the scaphotrapeziotrapezoid joint: A multi\u2010domain statistical shape modeling approach"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-3243","authenticated-orcid":false,"given":"Taylor P.","family":"Trentadue","sequence":"first","affiliation":[{"name":"Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation Mayo Clinic Rochester Minnesota USA"},{"name":"Mayo Clinic Medical Scientist Training Program, Mayo Clinic College of Medicine 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