{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:13:21Z","timestamp":1769606001142,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR42017"],"award-info":[{"award-number":["AR42017"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Progressive osteolysis can occur at the cement\u2013bone interface of joint replacements and the associated loss of fixation can lead to clinical loosening. We previously developed a rat hemiarthroplasty model that exhibited progressive loss of fixation with the development of cement\u2013bone gaps under the tibial tray that mimicked patterns found in human arthroplasty retrievals. Here we explored the ability of a bisphosphonate (zoledronic acid, ZA) to attenuate cement\u2013bone osteolysis and maintain implant stability. Sprague\u2010Dawley rats (<jats:italic>n<\/jats:italic>\u2009=\u200959) received a poly(methylmethacrylate) cemented tibial component and were followed for up to 12 weeks. Treatment groups included peri\u2010operative administration of ZA (ZA group), administration of ZA at 6 weeks postop (late ZA group), or vehicle (Veh group). There was a 60% reduction in the rate of cement\u2013bone gap formation for the ZA group (0.15\u2009mm<jats:sup>3<\/jats:sup>\/week) compared to Veh group (0.38\u2009mm<jats:sup>3<\/jats:sup>\/week, <jats:italic>p<\/jats:italic>\u2009=\u20090.016). Late ZA prevented further progression of gap formation but did not reverse bone loss to the level achieved in the ZA group. Micromotion from five times body weight toggle loading was positively correlated with cement\u2013bone gap volume (<jats:italic>p<\/jats:italic>\u2009=\u20090.009) and negatively correlated with the amount of cement in the metaphysis (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). Reduced new bone formation and enduring nonviable bone in the epiphysis for the ZA group were found. This suggests that low bone turnover in the epiphysis may suppress the early catabolic response due to implantation, thereby maintaining better fixation in the epiphysis. This preclinical model presents compelling supporting data documenting improved maintenance of the cement\u2013bone fixation with the use of peri\u2010operative bisphosphonates.<\/jats:p>","DOI":"10.1002\/jor.25941","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T13:54:25Z","timestamp":1721483665000},"page":"2693-2704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peri\u2010operative zoledronic acid attenuates peri\u2010prosthetic osteolysis in a rat model of cemented knee replacement"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-0740","authenticated-orcid":false,"given":"Kenneth A.","family":"Mann","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Institute for Human Performance SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark 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