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Understanding of disease pathogenesis has advanced substantially in the past decade, yet no disease\u2010modifying therapeutics have advanced to the clinic. To address this challenge, the CARE\u2010AP (Cartilage Repair strategies to alleviate Arthritis Pain) collaborative research team was convened to bring together relevant multidisciplinary expertise and perspectives from across the VA research community nationwide. The first CARE\u2010AP Annual Research Symposium took place (virtually) in February 2022 with roughly 90 participants. 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