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We hypothesized that a maternal high\u2010fat high\u2010sugar (HFHS) diet would promote spontaneous osteoarthritis\u2010related cartilage and bone changes in 1\u2010year\u2010old offspring. Female C57BL\/6\u2009J mice were placed on either a chow control or HFHS diet for 6 weeks before mating to a chow\u2010fed C57BL\/6\u2009J male and maintained on their assigned diets throughout pregnancy and lactation. Male and female offspring were weaned onto a chow diet, raised to 1 year of age, and evaluated for cartilage and bone changes indicative of OA. However, offspring did not show early signs of OA as measured by histological Mankin scoring, mechanical testing of the pericellular matrix, histological synovitis scoring, or subchondral bone thickening as measured by microcomputed Tomography. On the other hand, male offspring from HFHS\u2010fed dams had reduced trabecular bone quality in the tibial metaphysis and decreased cortical thickness. Although maternal HFHS diet did not impact trabecular or cortical bone quality in tibias of female offspring, the radii of these animals had decreased cortical thickness, increased medullary area, and impaired breaking strength compared to those of control\u2010fed dams. Finally, we evaluated bone quality and strength in male and female F2 offspring and found that the grandmaternal diet modestly impacted radial bone geometry but not strength. Together these results suggest that maternal HFHS diet impairs F1 offspring skeletal integrity in a sex and bone site\u2010specific manner.<\/jats:p>","DOI":"10.1002\/jor.25980","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T07:26:01Z","timestamp":1727594761000},"page":"117-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal high\u2010fat high\u2010sugar diet impairs bone quality and strength but not cartilage in aging mice"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-6715","authenticated-orcid":false,"given":"Arin K.","family":"Oestreich","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University in St. Louis St Louis Missouri USA"},{"name":"Shriners Hospitals for Children St. Louis Missouri USA"},{"name":"Center of Regenerative Medicine Washington University in St. Louis St. 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