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To evaluate cortical bone morphology quantitatively, we established a method to measure the distance from the center point of a cross\u2010section to the external and internal borders based on CT images. Using this method, 44 sides of a female femoral skeleton specimen were examined and areas of protrusion and thickening in the medial anterior and lateral posterior regions just below the lesser trochanter were identified. These positions strongly correlated with the anteversion angle, suggesting the involvement of the distribution of the load received from body weight defined by the angle. The finite element method was used to examine the relationships between the positions of these areas with compressive and tensile stress distribution areas in the one\u2010legged standing condition. The medial anterior region and lateral posterior region protruded and thickened in response to compressive and tensile stress, respectively. In addition, a hierarchical relationship was observed between the anteversion angle, tensile stress distribution, protrusion, and thickening in femurs with thinning of cortical bone, indicating that morphogenesis occurs adaptively to loading. The present results demonstrate the usefulness of this method in considering the formation mechanism and function of the femoral diaphysis and suggest that bone remodeling is necessary to maintain adaptability.<\/jats:p>","DOI":"10.1002\/jor.25983","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T12:39:04Z","timestamp":1727699944000},"page":"337-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The cross\u2010sectional morphology of the proximal femoral diaphysis is defined by the anteversion angle"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-240X","authenticated-orcid":false,"given":"Daisuke","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Macroscopic Anatomy, Graduate School of Biomedical Science Nagasaki University 1\u201012\u20104 Sakamoto, Nagasaki Nagasaki 852\u20108523 Japan"},{"name":"Center of 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