{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:44:20Z","timestamp":1787917460571,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR082973"],"award-info":[{"award-number":["R01AR082973"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"publisher","award":["707634"],"award-info":[{"award-number":["707634"]}],"id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003393","name":"L. J. Skaggs and Mary C. Skaggs Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The biological factors that affect healing after rotator cuff repair (RCR) are not well understood. Genetic variants in the extracellular matrix protein\n                    <jats:italic>Tenascin C<\/jats:italic>\n                    (\n                    <jats:italic>TNC<\/jats:italic>\n                    ) are associated with impaired tendon healing and it is expressed in rotator cuff tendon tissue after injury, suggesting it may have a role in the repair process. The purpose of the current study was to determine the role of TNC on tendon healing after RCR in a murine model. The supraspinatus tendon was transected and repaired on the left shoulder of wild\u2010type (WT\u2010RCR),\n                    <jats:italic>Tenascin C<\/jats:italic>\n                    null (\n                    <jats:italic>\n                      Tnc\n                      <jats:sup>\u2212<\/jats:sup>\n                      \u2010\n                    <\/jats:italic>\n                    RCR) and\n                    <jats:italic>Tnc<\/jats:italic>\n                    heterozygous (\n                    <jats:italic>\n                      Tnc\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    \u2010RCR) mice. Controls included the unoperated, contralateral shoulder of WT\u2010RCR,\n                    <jats:italic>Tnc<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2014<\/jats:italic>\n                    <\/jats:sup>\n                    RCR,\n                    <jats:italic>\n                      Tnc\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    \u2010RCR mice and unoperated shoulders from age and genotype matched controls. We performed histologic, activity testing, bulk RNA\u2010seq, and biomechanical analyses. At 8\u2010weeks post\u2010RCR,\n                    <jats:italic>\n                      Tnc\n                      <jats:sup>\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      Tnc\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice had severe bone and tendon defects following RCR.\n                    <jats:italic>\n                      Tnc\n                      <jats:sup>\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    \u2010RCR mice had reduced activity after RCR including reduced wheel rotations, wheel duration, and wheel episode average velocity compared with WT\u2010RCR. Loss of\n                    <jats:italic>Tnc<\/jats:italic>\n                    following RCR altered gene expression in the shoulder, including upregulation of sex hormone and WNT pathways and a downregulation of inflammation and cell cycle pathways.\n                    <jats:italic>\n                      Tnc\n                      <jats:sup>\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice had similar biomechanical properties after repair as WT. Further research is required to evaluate tissue specific alterations of\n                    <jats:italic>Tnc<\/jats:italic>\n                    , the interactions of\n                    <jats:italic>Tnc<\/jats:italic>\n                    and sex hormone and inflammation pathways as well as possible adjuvants to improve enthesis healing in the setting of reduced TNC function.\n                  <\/jats:p>","DOI":"10.1002\/jor.26025","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:45:54Z","timestamp":1732686354000},"page":"483-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tenascin C deletion impairs tendon healing and functional recovery after rotator cuff repair"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4112-0423","authenticated-orcid":false,"given":"Robert Z.","family":"Tashjian","sequence":"first","affiliation":[{"name":"Department of Orthopedics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Zitnay","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolas H.","family":"Kazmers","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9353-4591","authenticated-orcid":false,"given":"Shivakumar R.","family":"Veerabhadraiah","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C.","family":"Zelada","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Honeggar","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter N.","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Utah School of Medicine Salt Lake City Utah 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