{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T05:49:56Z","timestamp":1765777796750,"version":"3.48.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Enthesitis, or inflammation specific to sites in the body where tendon inserts into bone, can arise in isolated joints from overuse or in multiple joints as a complication of an autoimmune condition such as psoriatic arthritis or spondyloarthritis. However, the pathogenesis of enthesitis is not well understood, so treatment strategies are limited. A clinically relevant animal model of enthesitis would allow investigators to determine mechanisms driving the disease and evaluate novel therapies. Therefore, we developed a murine model of inducible enthesis\u2010specific inflammation by constitutively activating the NF\u2010\u03baB pathway in Gli1+ cells. Gli1Cre\n                    <jats:sup>ERT<\/jats:sup>\n                    mice were crossed with IKK\u03b2\u2010overexpression mice and given tamoxifen injections 5 days postnatally to induce enthesitis. Sixteen weeks of IKK\u03b2 overexpression in enthesis cells led to impaired mechanical properties, subtle histologic changes, and changes to expression of extracellular matrix\u2010 and inflammation\u2010related genes. Increased loading from treadmill overuse activity did not exacerbate this phenotype. Clinical significance: The new murine model may have utility for studying the pathogenesis of enthesitis and approaches to treat the condition.\n                  <\/jats:p>","DOI":"10.1002\/jor.26035","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T01:41:00Z","timestamp":1736473260000},"page":"719-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Mouse Model of Enthesis\u2010Specific NF\u2010\u03baB Activation"],"prefix":"10.1002","volume":"43","author":[{"given":"McKenzie E.","family":"Sup","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Columbia University New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam C.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of Michigan Ann Arbor Michigan 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